362477-53-0

Upstream product

• 63818-65-5 4-methoxylphenyl phosphonic acid monoethyl ester 
• 37632-18-1 4-methoxyphenylphosphonic dichloride 
• 3762-33-2 diethyl (p-methoxyphenyl)phosphonate 

Downstream Products

• 405175-82-8 (R)-4-[Ethoxy-(4-methoxy-phenyl)-phosphinoyl]-piperazine-1,3-dicarboxylic acid 1-benzyl ester 3-methyl ester 
• 592530-92-2 C₂₂H₃₁N₂O₅P 
• 652987-35-4 C₁₅H₂₄NO₅P 
• 592530-91-1 C₂₂H₃₀NO₅P 
• 405175-76-0 (7-benzyloxycarbamoyl-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl)-(4-methoxy-phenyl)-phosphinic acid ethyl ester 
• 362477-18-7 (3R)-N-benzyloxy-2-[ethoxy(4-methoxyphenyl)phosphoryl]-7-nitro-1,2,3,4-tetrahydroisoquinoline-3-carboxamide 
• 362476-85-5 (3R)-N-benzyloxy-2-[(RS)-ethoxy(4-methoxyphenyl)phosphoryl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide 
• 405175-83-9 ((R)-2-Benzyloxycarbamoyl-pyrrolidin-1-yl)-(4-methoxy-phenyl)-phosphinic acid ethyl ester 
• 405175-75-9 5-[ethoxy-(4-methoxyphenyl)phosphinoyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-6-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Encounter with unexpected collagenase-1 selective inhibitor: Switchover of inhibitor binding pocket induced by fluorine atom

Phosphonamide-based inhibitors having trifluoromethyl moiety showed highly selective inhibition against MMP-1. A possible mechanism of the selectivity of MMP-1 inhibitors through the switchover of the binding pocket was speculated by computational calculations. As a consequence of the unexpected selectivity, the specific interaction of CF3 group of the inhibitor and Arg214 in the S1′ pocket of MMP-1 conducted a low binding energy.

New type of metalloproteinase inhibitor: Design and synthesis of new phosphonamide-based hydroxamic acids

A series of phosphonamide-based hydroxamate derivatives were synthesized, and the inhibitory activities were evaluated against various metalloproteinases in order to clarify its selectivity profile. Among the four diastereomeric isomers resulting from the

Preparation of 3-substituted cephalosporins

There is described a process for preparing an enamine of formula (IX): STR1 where R2 is a carboxylic acid protecting group and R3 is the residue of a carboxylic acid derived acyl group and where R5 and R6 are the same or different C1-4 alkyl or C7-10 aralkyl groups; or taken together with the adjacent nitrogen atom form a heterocyclic ring containing from 4 to 8 carbon atoms and optionally a further heteroatom selected from oxygen and nitrogen; by reacting a compound of formula (XII): STR2 with an amine of formula HNR5 R6, the reactant of formula (XII) being prepared by reaction of an appropriate enol derivative with a phosphorus reagent. The enamines of formula (IX) are useful in the preparation of 3-hydroxycephalosporins.