65313-46-4

Basic information

• Product Name: 1-Hydroxyhexane-2,5-dione
• Synonyms: 1-Hydroxyhexane-2,5-dione
• CAS NO: 65313-46-4
• Molecular Formula: C₆H₁₀O₃
• Molecular Weight: 130.14
• Mol File: 65313-46-4.mol
• Article Data: 16

Chemical Properties

• Melting Point: 51 °C
• Boiling Point: 82-85 °C(Press: 0.5 Torr)
• Appearance: /
• Density: 1.090±0.06 g/cm3(Predicted)
• PKA: 12.95±0.10(Predicted)
• CAS DataBase Reference: 1-Hydroxyhexane-2,5-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Hydroxyhexane-2,5-dione(65313-46-4)
• EPA Substance Registry System: 1-Hydroxyhexane-2,5-dione(65313-46-4)

Safety Data

• Hazardous Substances Data: 65313-46-4(Hazardous Substances Data)

Usage

General Description

1-Hydroxyhexane-2,5-dione, also known as 3-hydroxy-5-hexanone, is a chemical compound with the molecular formula C6H10O3. It is a cyclic diketone that is commonly used as a building block in organic synthesis. 1-Hydroxyhexane-2,5-dione is known for its pleasant fruity odor and is used as a flavoring agent in the food industry. It is also used as a precursor in the production of pharmaceuticals and other fine chemicals. Additionally, it has been studied for its potential applications in various fields, including its use as a chelating agent and its role in the formation of molecular complexes. However, it is important to note that 1-Hydroxyhexane-2,5-dione is a potentially hazardous chemical and should be handled with caution.

Upstream product

• 67-47-0 5-hydroxymethyl-2-furfuraldehyde 
• 470-23-5 D-fructose 
• 57-48-7 D-Fructose 

Downstream Products

• 26629-21-0 2,3-dihydro-1H-1-methylcyclopenta(b)quinoxaline 
• 123-76-2 levulinic acid 
• 6126-49-4 tetrahydro-5-methyl-2-furanmethanol 
• 65709-88-8 Z-5-Hydroxy-hexen-2 
• 54560-70-2 (+/-)-(E)-hex-4-en-2-ol 
• 765-70-8 3-methyl-1,2-cyclopentanedione 
• 80-71-7 2-hydroxy-3-methylcyclopent-2-en-1-one 

Relevant articles and documents

Preparation of 1-Hydroxy-2,5-hexanedione from HMF by the Combination of Commercial Pd/C and Acetic Acid

The development of a simple and durable catalytic system for the production of chemicals from a high concentration of a substrate is important for biomass conversion. In this manuscript, 5-hydroxymethylfurfural (HMF) was converted to 1-hydroxy-2,5-hexanedione (HHD) using the combination of commercial Pd/C and acetic acid (AcOH) in water. The influence of temperature, H2 pressure, reaction time, catalyst amount and the concentration of AcOH and HMF on this transformation was investigated. A 68% yield of HHD was able to be obtained from HMF at a 13.6 wt% aqueous solution with a 98% conversion of HMF. The resinification of intermediates on the catalyst was characterized to be the main reason for the deactivation of Pd/C. The reusability of the used Pd/C was studied to find that most of the activity could be recovered by being washed in hot tetrahydrofuran.

Highly efficient hydrogenative ring-rearrangement of furanic aldehydes to cyclopentanone compounds catalyzed by noble metals/MIL-MOFs

Hydrogenative ring-rearrangement reaction of biomass-derived furanic aldehydes to cyclopentanone compounds catalyzed by metal/support bifunctional catalysts suffers a low selectivity of target product and serious carbon loss because of the Br?nsted acid catalysis. Herein, a series of pure Lewis acid sites MIL-MOFs (Fe-MIL-100, Fe-MIL-101 and Cr-MIL-101) with different crystal topology structures and metals are synthesized. Then the nanoparticles of Ru, Pt, Pd and Au are uniformly dispersed on the internal surface of the MOF support. The hydrogenation rate catalyzed by the noble metals/Fe-MIL-100 is three times faster than those obtained with Fe-MIL-101 and Cr-MIL-101-based catalysts due to the higher dispersion of nanoparticles on the former to make it more accessible to reactants. Meanwhile, both of the noble metals on Fe-MIL-100 and Fe-MIL-101 have a higher selectivity of cyclopentanone compounds than that on Cr-MIL-101, since the Fe ions in the MOF host with a higher oxophilicity will promote the adsorption and hydrolysis of the intermediate furanic alcohols (furfural alcohol or 2,5-bis(hydroxymethyl)furan). Furthermore, the noble metals/MIL-MOFs catalyst can maintain a good activity and stability after recycling for five runs. The current work will present an efficient catalytic reaction system for the hydrogenative ring-rearrangement of furfural and 5-hydroxymethyl furfural to synthesize cyclopentanone compounds.

Conversion of HMF to methyl cyclopentenolone using Pd/Nb2O5 and Ca-Al catalysts: Via a two-step procedure

The catalytic conversion of HMF to 2-hydroxy-3-methyl-2-cyclopenten-1-one (MCP), which is a valuable edible essence that has traditionally been obtained from adipic acid, was achieved with an isolated yield of 58%. This procedure comprised two steps: the hydrogenation of 5-hydroxymethylfurfural (HMF) to 1-hydroxy-2,5-hexanedione (HHD) in water on Pd/Nb2O5 catalysts and then the isomerization of HHD to MCP in the presence of a base. The Nb2O5 supports, which were acidic, were characterized by FTIR, XRD and NH3-TPD. The supported Pd/Nb2O5 catalysts, in which Pd was highly dispersed, were synthesized employing cyclohexene as a reductant and were characterized by XRD, TEM, ICP-AES, XPS, EDX and CO pulse chemisorption. The high conversion of HMF was attributed to the high dispersion of Pd, and the acidity of the supports led to high selectivity for HHD. The conversion of HHD to MCP was an intramolecular aldol condensation reaction, and the protonic solvent favored this reaction. Ca-Al was proved to be an effective solid base for the conversion of HHD to MCP in water.