65331-18-2

Upstream product

• 31021-05-3 (E)-2-(4-chlorobenzylidene)cyclohexanone 
• 17356-08-0 thiourea 
• 31020-78-7 2-(4-chlorobenzylidene)cyclohexan-1-one 
• 108-94-1 cyclohexanone 
• 104-88-1 4-chlorobenzaldehyde 

Downstream Products

• 1032365-99-3 4-(4-chlorophenyl)-3-(1-naphthylsulfonyl)-1,2,3,4,5,6,7,8-octahydroquinazoline-2-thione 
• 1032365-95-9 4-(4-chlorophenyl)-3-methylsulfonyl-1,2,3,4,5,6,7,8-octahydroquinazoline-2-thione 
• 709635-50-7 4-(4-chlorophenyl)-3-(4-chlorophenylsulfonyl)-1,2,3,4,5,6,7,8-octahydroquinazoline-2-thione 
• 1032365-93-7 4-(4-chlorophenyl)-3-phenylsulfonyl-1,2,3,4,5,6,7,8-octahydroquinazoline-2-thione 
• 1032366-02-1 4-(4-chlorophenyl)-3-(4-methylphenylsulfonyl)-1,2,3,4,5,6,7,8-octahydroquinazoline-2-thione 
• 1032365-97-1 4-(4-chlorophenyl)-3-(4-nitrophenylsulfonyl)-1,2,3,4,5,6,7,8-octahydroquinazoline-2-thione 
• 951645-58-2 5-(4-chloro-phenyl)-6,7,8,9,10,10a-hexahydro-5H-thiazolo[2,3-b]quinazolin-3-one 

Relevant academic research and scientific papers

Synthesis and biological activities of some new C-Aminomethylation of 5H-5-Aryl-6,7,8,9-tetrahydrothiazolo[2,3-b]quinazolin-3(2H)-one and 6H-6-Aryl-2,3,7,8,9,10-hexahydrothiazino[2,3-b]quinazolin-4(3H)-one

The synthesis of 5H-5-aryl-6,7,8,9-tetrahydrothiazolo[2,3-b]quinazolin-3(2H)-one and 6H-6-aryl-2,3,7,8,9,10-hexahydrothiazino[2,3-b]quinazolin-4(3H)-one, reaction between 4-aryl-3,4,5,6,7,8-hexahydroquinazolin-2-thione and methyl chloroacetate and ethyl β-bromo propionate. The Mannich reaction on 5H-5-aryl-6,7,8,9-tetrahydrothiazolo[2,3-b]quinazolin-3(2H)-one and 6H-6-aryl-2,3,7,8,9,10-hexahydrothiazino[2,3-b]quinazolin-4(3H)-one in ethanol, aqueous formaldehyde and different secondary amines yielded a single product C-Mannich base in each case. The obtained C-Mannich bases (compounds VIII and X) have been characterized on the basis of analytical spectral data. These C-Mannich bases have been screened for their antibacterial, antifungal, anti-inflammatory and analgesic activities.

3,4-Disubstituted-1,2,3,4,5,6,7,8-octahydroquinazoline-2-thiones: Synthesis, antimicrobial evaluation and QSAR investigations using Hansch analysis

The 3,4-disubstituted-1,2,3,4,5,6,7,8-octahydroquinazoline-2-thione derivatives were synthesized and characterized by physicochemical and spectral means, and the results of antimicrobial study of these compounds against Staphylococcus aureus, Escherichia

Development of new molecular entities as potent non-steroidal non-acidic anti-inflammatory agents - Part-I: Synthesis of some substituted pyrazolo-[3,4-a] thiozolo [2′,3'-b] quinazolines

Eight 6-aryl-2,3,4,5-tetrahydro-7,8,9,10-tetrahydro-11H-pyrazolo [3,4-a] thiazolo [2,3-b] quinazolines were prepared 5a-h from the respective 5H-5-aryl-6,7,8,9-tetrahydro thiazolo[2,3-b]quinazolin-3(2H)-ones by a cycloaddition reaction of hydrazine/phenyl

Highly chemoselective multicomponent biginelli-type condensations of cycloalkanones, urea or thiourea and aldehydes

The classical Biginelli reaction is considerably extended by use of cycloalkanones instead of 1,3-dicarbonyl compounds. Use of TMSCl as a Lewis acid allowed one-pot chemoselective multicomponent Biginelli reactions between cycloalkanones, urea or thiourea, and aldehydes. Under similar reaction conditions, thiourea exhibited different behavior to urea, and aliphatic aldehydes showed lower reactivity than aromatic aldehydes. A possible mechanism to account for the reaction is proposed. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005.