65341-59-5

Upstream product

• 93-17-4 3,4-dimethoxyphenylacetonitrile 
• 66003-76-7 Diphenyliodonium triflate 
• 93-40-3 (3,4-Dimethoxyphenyl)acetic acid 

Downstream Products

• 65341-60-8 [2-(3,4-dimethoxyphenyl)ethyl]phenylamine 
• 117197-25-8 (3,4-dimethoxy-6-nitro-phenyl)-acetic acid anilide 
• 96719-37-8 1-(2-Chloro-phenyl)-6,7-dimethoxy-2-phenyl-3,4-dihydro-isoquinolinium; iodide 
• 96719-38-9 1-(2-Fluoro-phenyl)-6,7-dimethoxy-2-phenyl-3,4-dihydro-isoquinolinium; iodide 
• 96719-69-6 1-(2-Chloro-phenyl)-6,7-dimethoxy-2-phenyl-1,2,3,4-tetrahydro-isoquinoline 
• 96719-70-9 1-(2-Fluoro-phenyl)-6,7-dimethoxy-2-phenyl-1,2,3,4-tetrahydro-isoquinoline 
• 96719-04-9 2-Chloro-N-[2-(3,4-dimethoxy-phenyl)-ethyl]-N-phenyl-benzamide 
• 96719-05-0 N-[2-(3,4-Dimethoxy-phenyl)-ethyl]-2-fluoro-N-phenyl-benzamide 

Relevant academic research and scientific papers

Copper-catalyzed transformation of alkyl nitriles to N -arylacetamide using diaryliodonium salts

This work reports a simple and efficient method for the copper-catalyzed redox-neutral transformation of alkyl nitriles using eco-friendly diaryliodonium salts and leading to N-arylacetamides. The method features high efficiency, broad substrate scope and good functional group tolerance.

THE REACTION OF 1-ALKYLDIHYDROISOQUINOLINES WITH BENZYNE. AN UNEXPECTED ENTRY TO DIBENZINDOLIZINES.

The reaction of 1-ethylidene-2-formyl-1,2,3,4-tetrahydroisoquinolines 4a and 4b, or 1-ethyl-3,4-dihydroisoquinolines 3a and 3b, with benzyne led, by a formal 3+2 cycloaddition, to dibenzindolizines 5a and 5b, respectively.Compound 5b was also synthesized

Antiimplantation Agents: Part II - 1,2-Diaryl-1,2,3,4-tetrahydroisoquinolines

1,2-Diaryl-3,4-dihydroisoquinolinium derivatives (5) have been synthesised from N-aryl-N-aroyl-β-phenethylamines (4) and found to exhibit no antiimplantation activity in the rat whereas many of the corresponding tetrahydroisoquinolines (6) are active.Structure-activity relationships have also been studied. 1-(p-Fluorophenyl)-6-methoxy-2-phenyl-1,2,3,4-tetrahydroisoquinoline (6u) and its nor derivative (6v) are very potent, while the ortho (6g) and the meta (6n) fluoro analogues as well as the des-fluoro derivative (6d) are quite active.Extensive biological tests have been carried out on 6g.The enantiomers (+)-6p*HCl and (-)-6q*HCl of 6n have similar activity profiles as that of 6n showing no separation of antiimplantation and estrogenic properties.Diastereomeric 2-(2-methyl-2-phenethyl)-1-phenyl-1,2,3,4-tetrahydroisoquinolines (13a and 13b) show similar properties, while the tetracyclic derivative 19 is inactive. 2-Phenoxyethyl-1-phenyl-1,2,3,4-tetrahydroisoquinoline (26) shows moderate activity, but 1-(β-phenethyl)-2-phenyl-1,2,3,4-tetrahydroisoquinoline 29 is inactive.