653579-37-4Relevant academic research and scientific papers
A simple ketone as an efficient metal-free catalyst for visible-light-mediated Diels-Alder and aza-Diels-Alder reactions
Kollmann, Jiri,Zhang, Yu,Schilling, Waldemar,Zhang, Tong,Riemer, Daniel,Das, Shoubhik
supporting information, p. 1916 - 1920 (2019/04/29)
Diels-Alder reactions are highly effective between electron-rich dienes and electron-poor dienophiles. However, these reactions with electron-rich dienophiles are limited and require forcing conditions. Based on this, an efficient metal-free homogeneous s
Iridium-Catalyzed Reductive Alkylations of Secondary Amides
Ou, Wei,Han, Feng,Hu, Xiu-Ning,Chen, Hang,Huang, Pei-Qiang
supporting information, p. 11354 - 11358 (2018/08/28)
Reported herein is the first direct, metal-catalyzed reductive functionalization of secondary amides to give functionalized amines and heterocycles. The method is shown to have exceptionally broad scope with respect to suitable nucleophiles, which cover both hard and soft C nucleophiles as well as a P nucleophile. The reaction exhibits good chemoselectivity and tolerates several sensitive functional groups.
2-halogenoimidazolium salt catalyzed aza-diels-alder reaction through halogen-bond formation
Takeda, Youhei,Hisakuni, Daichi,Lin, Chun-Hsuan,Minakata, Satoshi
supporting information, p. 318 - 321 (2015/01/30)
2-Halogenoimidazolium salts are found to catalyze aza-Diels-Alder reaction of aldimines with Danishefsky diene in an efficient manner. Comparative studies and titration experiments support the formation of halogen bonding between imines and catalysts.
Two-step metal-mediated transformation of isoxazolidine-5- spirocyclopropanes into pyridone derivatives
Revuelta, Julia,Cicchi, Stefano,Brandi, Alberto
, p. 5636 - 5642 (2007/10/03)
The two-step metal-catalyzed overall transformation of isoxazolidine-5- spirocyclopropanes into the corresponding dihydro- and tetrahydropyridones is described. The first step is the chemoselective reduction of the N-O bond of the isoxazolidine ring prese
Synthesis of β-amino acids based on oxidative cleavage of dihydropyridone derivatives
Ege, Markus,Wanner, Klaus T.
, p. 3553 - 3556 (2007/10/03)
(Chemical Equation Presented) A new method for the synthesis of β-amino acids based on 2,3-dihydropyridones as starting materials is presented. Conversions of 2,3-dihydropyridones with NaIO4 and subsequently with base gave the corresponding β-amino acids in a one-pot procedure. The reactions have been monitored by 1H NMR indicating that the β-amino acids were formed in quantitative yields mostly. This method appears to be of broad scope, as 2-substituted 2,3-dihydropyridones are easily accessible via N-acyliminium ions generated from 4-methoxypyridine.
Domino Palladium(II)-Mediated Rearrangement-Oxidative Cyclization of β-Aminocyclopropanols
Cicchi, Stefano,Revuelta, Julia,Zanobini, Alessandra,Betti, Matteo,Brandi, Alberto
, p. 2305 - 2308 (2007/10/03)
β-Aminocyclopropanols were transformed, in a domino process catalyzed by Pd(II) salts, into the corresponding 2,3-dihydro-1H-pyridin-4-ones. Conversely the use of a Pd(0) derivative, Pd(dba)2, afforded the corresponding tetrahydropyrid-4-ones. The saturated derivatives were also obtained, in better yields, using Pd(II) and Cu(OAc)2 as stoichiometric oxidant.
