214626-96-7

Upstream product

• 620-08-6 4-methoxypyridine 
• 98-88-4 benzoyl chloride 
• 100-58-3 phenylmagnesium bromide 
• 626-64-2 pyridin-4-ol 
• 100-59-4 phenylmagnesium chloride 

Downstream Products

• 126378-84-5 (RS)-2-phenyl-2,3-dihydro-1H-pyridin-4-one 
• 471259-71-9 (RS)-3-amino-3-phenyl-propionic acid hydrochloride 
• 653579-37-4 (RS)-1-methyl-2-phenyl-2,3-dihydro-1H-pyridin-4-one 
• 1232685-93-6 N-(2-bromo-4,5-dimethoxyphenyl)-4-oxo-2-phenyl-2,3-dihydropyridine-1-carboxamide 
• 1232685-94-7 N-(2-bromo-4-chloro-5-methoxyphenyl)-4-oxo-2-phenyl-2,3-dihydropyridine-1-carboxamide 
• 1232685-96-9 (2S)-N-(2-bromo-4-chloro-5-methoxyphenyl)-4-oxo-2-phenyl-2,3-dihydropyridine-1-carboxamide 
• 1585185-07-4 C₁₈H₁₅NO₂ 
• 1585185-09-6 C₂₁H₁₉NO₂ 

Relevant academic research and scientific papers

Solid phase synthesis of N-acyl-2-substituted-dihydro-4-pyridone: Resin activation/capture approach/REACAP technology

Resin Activation/Capture (REACAP) Technology was used to prepare N- acyl-2-substituted-dihydro-4-pyridone analogs.

Novel Series of Dihydropyridinone P2X7 Receptor Antagonists

Identification of singleton P2X7 inhibitor 1 from HTS gave a pharmacophore that eventually turned into potential clinical candidates 17 and 19. During development, a number of issues were successfully addressed, such as metabolic stability, plasma stability, GSH adduct formation, and aniline mutagenicity. Thus, careful modification of the molecule, such as conversion of the 1,4-dihydropyridinone to the 1,2-dihydropyridinone system, proper substitution at C-5″, and in some cases addition of fluorine atoms to the aniline ring allowed for the identification of a novel class of potent P2X7 inhibitors suitable for evaluating the role of P2X7 in inflammatory, immune, neurologic, or musculoskeletal disorders.

Synthesis of β-amino acids based on oxidative cleavage of dihydropyridone derivatives

(Chemical Equation Presented) A new method for the synthesis of β-amino acids based on 2,3-dihydropyridones as starting materials is presented. Conversions of 2,3-dihydropyridones with NaIO4 and subsequently with base gave the corresponding β-amino acids in a one-pot procedure. The reactions have been monitored by 1H NMR indicating that the β-amino acids were formed in quantitative yields mostly. This method appears to be of broad scope, as 2-substituted 2,3-dihydropyridones are easily accessible via N-acyliminium ions generated from 4-methoxypyridine.