653579-77-2

Upstream product

• 653579-65-8 7-benzyloxy-2-bromo-3,4-dihydro-6-methoxy-1-naphthaldehyde 
• 653579-83-0 4-(4-benzyloxy-3-methoxyphenyl)-1-diazobutan-2-one 
• 116185-11-6 benzyl 3-[4-(benzyloxy)-3-methoxyphenyl]propanoate 
• 127399-66-0 1,2,3,4-tetrahydro-7-(benzyloxy)-6-methoxy-2(1H)-naphthalenone 
• 1135-24-6 (E)-3-(4-hydroxy-3-methoxyphenyl)acrylic acid 
• 653579-71-6 7-benzyloxy-3,4-dihydro-6-methoxy-2-(4,5-methylenedioxy-2-nitrophenyl)-1-naphthaldehyde 
• 105245-81-6 3-(4-benzyloxy-3-methoxyphenyl)propionic acid chloride 
• 30034-49-2 β-(4-benzyloxy-3-methoxyphenyl)propionic acid 
• 1135-23-5 3-(4-hydroxy-3-methoxyphenyl)propionic acid 

Relevant academic research and scientific papers

8,9-Methylenedioxybenzo[i]phenanthridines: Topoisomerase I-targeting activity and cytotoxicity

Substituted benzo[i]phenanthridines that have incorporated within their structure an 8,9-methylenedioxy group can exhibit topoisomerase I-targeting activity. Structure-activity studies were performed to examine the influence of saturation at the 11,12-positions of several substituted 8,9-methylenedioxybenzo[i]phenanthridines. The activities of these dihydro analogues were compared to those of their unsaturated analogues. In addition, the influence of varying substituents at the 2- and 3-positions within the A-ring of these 8,9-methylenedioxybenzo[i]phenanthridines on their relative potency as topoisomerase I-targeting agents and cell proliferation as determined using the MTT assay was investigated. 2,3-Dimethoxy-8,9-methylenedioxybenzo[i]phenanthridine and its 11,12-dihydro derivative were among the more potent analogues evaluated with regard to topoisomerase I-targeting activity and cytotoxicity.