653592-20-2Relevant academic research and scientific papers
Heterocyclic thrombin inhibitors. Part 1: Design and synthesis of amidino-phenoxy quinoline derivatives
Ries, Uwe J.,Priepke, Henning W. M.,Hauel, Norbert H.,Haaksma, Eric E. J.,Stassen, Jean M.,Wienen, Wolfgang,Nar, Herbert
, p. 2291 - 2295 (2003)
Amidino-phenoxy quinoline derivatives represent a new class of potent thrombin inhibitors with good selectivity and remarkably low molecular weight (MW: 335-391). X-ray analyses of thrombin-bound inhibitors revealed that enzyme inhibition is mainly based on hydrophobic interactions.
