653598-75-5Relevant academic research and scientific papers
Synthesis of 3, 5-diazabicyclo [5.1.0] octenes. A new platform to mimic glycosidase transition states
Leonik, Fedra M.,Ghiviriga, Ion,Horenstein, Nicole A.
experimental part, p. 5566 - 5572 (2010/11/18)
All-cis 1-hydroxymethyl 2, 3 bis-aminomethyl cyclopropane was used to construct the first 3, 5- diazabicyclo [5.1.0]-3-octenes. This system has the interesting ability to exist in a conformation that resembles a snapshot of a glycoside hydrolysis reaction
(2S,1′S,2′R,3′R)-2-(2′-Carboxy-3′ -hydroxymethylcyclopropyl) Glycine Is a Highly Potent Group 2 and 3 Metabotropic Glutamate Receptor Agonist with Oral Activity
Collado, Iván,Pedregal, Concepción,Bueno, Ana Belén,Marcos, Alicia,González, Rosario,Blanco-Urgoiti, Jaime,Pérez-Castells, Javier,Schoepp, Darryle D.,Wright, Rebecca A.,Johnson, Bryan G.,Kingston, Ann E.,Moher, Eric D.,Hoard, David W.,Griffey, Kelly I.,Tizzano, Joseph P.
, p. 456 - 466 (2007/10/03)
The asymmetric synthesis and biological activity of (2S, 1′S,2′R,3′R)-2-(2′-carboxy-3′ -hydroxymethylcyclopropyl) glycine ((+)-3) is described. This novel C-3′ substituted carboxy cyclopropyl glycine is a highly potent group 2 and group 3 mGluR agonist that has proven to be orally active in both fear potentiated startle (animal model for anxiety) and PCP-induced motor activation (animal model for psychosis) assays in rats.
