653599-89-4Relevant academic research and scientific papers
Novel Applications of the Sch?llkopf Chiral Auxiliary: A New and Efficient Enantioselective Synthesis of β-Lactams Possessing a C-4 Quaternary Stereocenter
Vassiliou, Stamatia,Dimitropoulos, Constantinos,Magriotis, Plato A.
, p. 2398 - 2400 (2003)
A new method for the enantioselective synthesis of substituted β-lactams is described based upon an improved alkylation of substituted Scho?llkopf chiral auxiliaries by α-haloacetate esters, employing tert-butyllithium as the deprotonating base, and the efficient conversion of the resulting quaternary 2,5-diketopiperazines to the targeted β-lactams.
