65361-84-4

Usage

Uses

Used in Medicinal Chemistry:
1-(4-(Benzyloxy)-1H-indazol-1-yl)ethanone is used as a chemical intermediate for the synthesis of pharmaceuticals due to its potential biological activity. Its unique structure allows for further functionalization and modification to create new compounds with therapeutic properties.
Used in Organic Synthesis:
In the field of organic synthesis, 1-(4-(Benzyloxy)-1H-indazol-1-yl)ethanone is used as a building block for constructing more complex organic molecules. Its versatile structure and functional groups facilitate the creation of a wide range of chemical entities for various applications, including pharmaceuticals, agrochemicals, and materials science.
Used in Drug Discovery:
1-(4-(Benzyloxy)-1H-indazol-1-yl)ethanone is utilized in drug discovery processes as a starting point for the development of new therapeutic agents. Its indazole core and functional groups can be optimized to target specific biological pathways or receptors, potentially leading to the discovery of novel drugs with improved efficacy and selectivity.
Used in Chemical Research:
In the realm of chemical research, 1-(4-(Benzyloxy)-1H-indazol-1-yl)ethanone serves as a subject of study to explore its reactivity, stability, and potential transformations. Understanding its chemical properties can contribute to the advancement of synthetic methodologies and the development of new synthetic routes to access complex organic molecules.

Upstream product

• 65361-83-3 (3-acetamino-2-methyl-phenyl)-benzyl ether 

Downstream Products

• 850364-08-8 4-(benzyloxy)-1H-indazole 
• 850363-66-5 4-(benzyloxy)-5-bromo-1H-indazole 

Relevant academic research and scientific papers

Protective Agent for Retinal Neuronal Cell Comprising Indazole Derivative as Active Ingredient

As a result of intensive studies for the purpose of finding a new medicinal use of an indazole derivative, it was found that an indazole derivative inhibits glutamate-induced retinal neuronal cell death in rat fetal retinal neuronal cells, in other words, the indazole derivative acts directly on the retinal neuronal cells and exhibits an effect of protecting retinal neuronal cells. Accordingly, the indazole derivative is useful for the prevention or treatment of an eye disease associated with retinal neuronal cell damage or retinal damage.

PROTECTIVE AGENT FOR RETINAL NEURONAL CELL COMPRISING INDAZOLE DERIVATIVE AS ACTIVE INGREDIENT

As a result of intensive studies for the purpose of finding a new medicinal use of an indazole derivative, it was found that an indazole derivative inhibits glutamate-induced retinal neuronal cell death in rat fetal retinal neuronal cells, in other words, the indazole derivative acts directly on the retinal neuronal cells and exhibits an effect of protecting retinal neuronal cells. Accordingly, the indazole derivative is useful for the prevention or treatment of an eye disease associated with retinal neuronal cell damage or retinal damage.

NOVEL INDAZOLE DERIVATIVE

An object of the present invention is to create a novel indazole derivative useful as a drug and to find a novel pharmacological action of the derivative. The compound of the present invention is represented by the formula [I] and has an excellent Rho kinase inhibiting action. In the formula, a ring X is a benzene ring or a pyridine ring; R1 and R2 are H or alkyl; R3 and R4 are halogen, H, OH, alkoxy, alkenyloxy, alkynyloxy, cycloalkyloxy, cycloalkenyloxy, aryloxy, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, carboxy, hydrocarbonyl, alkylcarbonyl, etc.; and R5 is halogen atom, H, OH, alkoxy, aryloxy, alkyl or aryl. Each group can be substituted.

INDAZOLYL-(4)-OXYPROPANOLAMINE COMPOUNDS AND THERAPEUTIC COMPOSITIONS

New indazolyl-(4)-oxypropanolamine compounds of the formula STR1 wherein R 1 is hydrogen or lower alkyl; and R 2 is straight-chain or branched lower alkyl which can be substituted by lower alkylthio;AND THE PHARMACOLOGICALLY COMPATIBLE SALTS T

INDAZOLE COMPOUNDS

Indazole compounds of the formula STR1 wherein R 1 is hydrogen or lower alkyl,R' is hydrogen or acyl, e.g., alkanoyl, andR 2 is benzyl or a radical of the general formula STR2 in which X is a reactive residue and Y is hydroxyl or X and Y toget