850363-66-5

Basic information

• Product Name: 1H-Indazole, 5-bromo-4-(phenylmethoxy)-
• Synonyms: 4-benzyloxy-5-bromo-1H-indazole
• CAS NO: 850363-66-5
• Molecular Formula: C14H11BrN2O
• Molecular Weight: 303.158
• Mol File: 850363-66-5.mol

Chemical Properties

• CAS DataBase Reference: 1H-Indazole, 5-bromo-4-(phenylmethoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indazole, 5-bromo-4-(phenylmethoxy)-(850363-66-5)
• EPA Substance Registry System: 1H-Indazole, 5-bromo-4-(phenylmethoxy)-(850363-66-5)

Safety Data

• Hazardous Substances Data: 850363-66-5(Hazardous Substances Data)

Usage

Chemical Class

Indazoles

Heterocyclic Aromatic Compound

Yes

Substituent

5-bromo-4-(phenylmethoxy)

Potential Pharmacological Activities

Anti-inflammatory, antimicrobial, and antifungal properties

Industries for Further Study and Development

Pharmaceutical and agricultural industries.

Upstream product

• 202857-88-3 2-Benzyloxy-1-bromo-4-fluoro-benzene 
• 1469327-04-5 2-(benzyloxy)-3-bromo-6-fluorobenzaldehyde 
• 100-39-0 benzyl bromide 
• 147460-41-1 2-bromo-5-fluorophenol 
• 65361-84-4 1-acetyl-4-benzyloxy-1H-indazole 

Downstream Products

• 1469327-05-6 tert-butyl 4-[4-(benzyloxy)-5-bromo-1H-indazole-1-yl]piperidine-1-carboxylate 
• 1469327-06-7 tert-butyl 4-[4-(benzyloxy)-5-methyl-1H-indazole-1-yl]piperidine-1-carboxylate 
• 850363-71-2 4-benzyloxy-5-bromo-2-(tetrahydropyran-2-yl)-2H-indazole 
• 850363-80-3 4-benzyloxy-5-bromo-1-(tetrahydropyran-2-yl)-1H-indazole 

Relevant articles and documents

PHARMACEUTICALS CONTAINING NOVEL 1-POSITION SUBSTITUTED INDAZOLE DERIVATIVE

PROBLEM TO BE SOLVED: To provide pharmaceuticals containing a compound having strong effect of modulating α7 nicotinic acetylcholine receptor (α7nAChR) and useful as treatment agent for diseases related to cholinergic in central nervous system (CNS) and/o

NOVEL 1-SUBSTITUTED INDAZOLE DERIVATIVE

A medicament for treating diseases associated with cholinergic properties in the central nervous system (CNS) and/or peripheral nervous system (PNS), diseases associated with smooth muscle contraction, endocrine disorders, neurodegenerative disorders and

Protective Agent for Retinal Neuronal Cell Comprising Indazole Derivative as Active Ingredient

As a result of intensive studies for the purpose of finding a new medicinal use of an indazole derivative, it was found that an indazole derivative inhibits glutamate-induced retinal neuronal cell death in rat fetal retinal neuronal cells, in other words, the indazole derivative acts directly on the retinal neuronal cells and exhibits an effect of protecting retinal neuronal cells. Accordingly, the indazole derivative is useful for the prevention or treatment of an eye disease associated with retinal neuronal cell damage or retinal damage.

PROTECTIVE AGENT FOR RETINAL NEURONAL CELL COMPRISING INDAZOLE DERIVATIVE AS ACTIVE INGREDIENT

As a result of intensive studies for the purpose of finding a new medicinal use of an indazole derivative, it was found that an indazole derivative inhibits glutamate-induced retinal neuronal cell death in rat fetal retinal neuronal cells, in other words, the indazole derivative acts directly on the retinal neuronal cells and exhibits an effect of protecting retinal neuronal cells. Accordingly, the indazole derivative is useful for the prevention or treatment of an eye disease associated with retinal neuronal cell damage or retinal damage.

NOVEL INDAZOLE DERIVATIVE

An object of the present invention is to create a novel indazole derivative useful as a drug and to find a novel pharmacological action of the derivative. The compound of the present invention is represented by the formula [I] and has an excellent Rho kinase inhibiting action. In the formula, a ring X is a benzene ring or a pyridine ring; R1 and R2 are H or alkyl; R3 and R4 are halogen, H, OH, alkoxy, alkenyloxy, alkynyloxy, cycloalkyloxy, cycloalkenyloxy, aryloxy, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, carboxy, hydrocarbonyl, alkylcarbonyl, etc.; and R5 is halogen atom, H, OH, alkoxy, aryloxy, alkyl or aryl. Each group can be substituted.