65375-93-1Relevant academic research and scientific papers
First synthesis of H-phosphonate oligonucleotides bearing N-unmodified bases
Wada, Takeshi,Honda, Fumio,Sato, Yuichi,Sekine, Mitsuo
, p. 915 - 918 (1999)
Oligodeoxyribonucleotides bearing H-phosphonate internucleotidic linkages and unmodified nucleobases were synthesized for the first time by the new H-phosphonate method using N-unprotected monomers. The 6-hydroxyhexyl phosphonates at both the 5' and 3' ends were found to be highly effective for stabilization of the H-phosphonate oligonucleotides. Solid-phase synthesis of H-phosphonate oligodeoxyribonucleotides containing dA, dC, dG, and T was achieved.
