Tetrahedron Letters p. 915 - 918 (1999)
Update date:2022-07-30
Topics:
Wada, Takeshi
Honda, Fumio
Sato, Yuichi
Sekine, Mitsuo
Oligodeoxyribonucleotides bearing H-phosphonate internucleotidic linkages and unmodified nucleobases were synthesized for the first time by the new H-phosphonate method using N-unprotected monomers. The 6-hydroxyhexyl phosphonates at both the 5' and 3' ends were found to be highly effective for stabilization of the H-phosphonate oligonucleotides. Solid-phase synthesis of H-phosphonate oligodeoxyribonucleotides containing dA, dC, dG, and T was achieved.
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