65383-34-8Relevant academic research and scientific papers
New synthetic approach for the preparation of imidazole N3-oxide
Cerecetto, Hugo,Gerpe, Alejandra,Gonzalez, Mercedes,Fernandez Sainz, Yolanda,Piro, Oscar E.,Castellano, Eduardo E.
, p. 2678 - 2684 (2007/10/03)
A new synthetic procedure of 1-alkyl(aryl)-1H-4-methylimidazole N 3-oxide derivatives by cyclocondensation of α-amineoximes and orthoesters was studied. Low yields in the cyclization process were the result of predominant Z-stereoisomer around the oxime moiety of α-amineoxime reactants. Different attempts to improve these yields were assayed, mild conditions being those that produce the best results. Also, the special acidity of hydrogen-2 in the imidazole N3-oxide system was studied in solution by NMR spectroscopy. This property provides a convenient intermediate to access 2-substituted analogues.
Novel antiprotozoal products: imidazole and benzimidazole N-oxide derivatives and related compounds.
Aguirre, Gabriela,Boiani, Mariana,Cerecetto, Hugo,Gerpe, Alejandra,Gonzalez, Mercedes,Sainz, Yolanda Fernandez,Denicola, Ana,De Ocariz, Carmen Ochoa,Nogal, Juan Jose,Montero, David,Escario, Jose Antonio
, p. 259 - 270 (2007/10/03)
The syntheses and biological evaluation of the first anti-protozoa imidazole N-oxide and benzimidazole N-oxide and their derivatives are reported. They were tested in vitro against two different protozoa, Trypanosoma cruzi and Trichomonas vaginalis. Deriv
