1582270-97-0

Basic information

• Product Name: 1-((3-(3-fluorophenyl)isoxazol-5-yl)methyl)-6-methyl-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile
• Synonyms: 1-((3-(3-fluorophenyl)isoxazol-5-yl)methyl)-6-methyl-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile
• CAS NO: 1582270-97-0
• Molecular Weight: 377.298
• Mol File: 1582270-97-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-((3-(3-fluorophenyl)isoxazol-5-yl)methyl)-6-methyl-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 1-((3-(3-fluorophenyl)isoxazol-5-yl)methyl)-6-methyl-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile(1582270-97-0)
• EPA Substance Registry System: 1-((3-(3-fluorophenyl)isoxazol-5-yl)methyl)-6-methyl-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile(1582270-97-0)

Safety Data

• Hazardous Substances Data: 1582270-97-0(Hazardous Substances Data)

Upstream product

• 367-57-7 1,1,1-Trifluoro-2,4-pentanedione 
• 1582270-75-4 6-methyl-2-oxo-1-(prop-2-yn-1-yl)-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile 
• 458-02-6 3-fluorobenzaldehyde oxime 
• 654-49-9 6-methyl-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile 

Relevant articles and documents

Synthesis, characterization and antitumor activity of novel triazole/isoxazole tagged pyridine hybrids

A series of novel 2-((1-substituted-1H-1,2,3-triazol-4-yl/3- substitutedisoxazol-5-yl)methoxy) substituted pyridine, 1-((1-substituted-1H-1, 2,3-triazol-4-yl/3-substitutedisoxazol-5-yl)methyl)substituted pyridin-2(1H)-one was prepared from 2-oxo-6-phenyl/methyl-4-(trifluoromethyl)-1,2- dihydropyridine-3-carbonitrile 3 via propargylation followed by 1,3-dipolar cycloaddition of the propargyl derivatives 4 and 5. These triazole/isoxazole tagged pyridine derivatives were evaluated for antitumor activity against breast cancer cell lines such as MDA-MB-231, MCF-7 etc. The results indicated that compounds 6e, 6f, 8e and 8f were found to be active on MDA-MB-231, while 6h and 8h were active on MCF-7.