654-83-1

Basic information

• Product Name: 5-methoxy-2-(trifluoromethyl)aniline
• Synonyms: 5-methoxy-2-(trifluoromethyl)aniline
• CAS NO: 654-83-1
• Molecular Weight: 191.153
• Mol File: 654-83-1.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 5-methoxy-2-(trifluoromethyl)aniline(CAS DataBase Reference)
• NIST Chemistry Reference: 5-methoxy-2-(trifluoromethyl)aniline(654-83-1)
• EPA Substance Registry System: 5-methoxy-2-(trifluoromethyl)aniline(654-83-1)

Safety Data

• Hazardous Substances Data: 654-83-1(Hazardous Substances Data)

Upstream product

• 75-63-8 Bromotrifluoromethane 
• 536-90-3 m-Anisidine 
• 25889-37-6 4-methoxy-2-nitro-1-(trifluoromethyl)benzene 
• 887144-94-7 Togni's reagent II 

Downstream Products

• 1417658-21-9 C₁₅H₁₁ClF₃NO₃ 
• 54486-53-2 2-Chloro-N-(2-methoxy-ethyl)-N-(5-methoxy-2-trifluoromethyl-phenyl)-acetamide 

Relevant articles and documents

Nickel-Catalyzed Direct C-H Trifluoromethylation of Free Anilines with Togni's Reagent

An efficient nickel-catalyzed C-H trifluoromethylation for the synthesis of trifluoromethylated free anilines using Togni's reagent has been developed. This approach exhibits a good functional group tolerance, good regioselectivity, and chemoselectivity under mild conditions. The newly developed economical one-step method is a better alternative to synthesize trifluoromethylated free anilines.

SMALL MOLECULE INHIBITORS OF GALECTIN-3

The present disclosure relates to compounds of formula I, which inhibit Gal-3, and include pharmaceutically acceptable salts, compositions comprising such compounds, and methods using and making such compounds and compositions.

Reactions of Trifluoromethyl Bromide and Related Halides: Part 10. Perfluoroalkylation of Aromatic Compounds induced by Sulphur Dioxide Radical Anion Precursors

Perfluoroalkylation of electron-rich aromatic compounds with trifluoromethyl bromide, or long-chain perfluoroalkyl iodides, was performed in the presence of sodium dithionite or zinc-sulphur dioxide.This alkylation occurred at the ortho and para positions relative to the amino or hydroxy substitutent.Pyrroles were perfluoroalkylated regioselectively at the 2-position.This alkylation was interpreted as a radical aromatic substitution; the formation of the perfluoroalkyl radical can be induced by a single-electron transfer from sulphur dioxide radical anion to the perfluoroalkyl halide.