5-Methoxy-2-(trifluoromethyl)aniline

Base Information

Chemical Name:5-Methoxy-2-(trifluoromethyl)aniline
CAS No.:654-83-1
Molecular Formula:C₈H₈F₃NO
Molecular Weight:191.153
Hs Code.:
European Community (EC) Number:965-834-8

Synonyms:5-methoxy-2-(trifluoromethyl)aniline;654-83-1;2-AMINO-4-METHOXYBENZOTRIFLUORIDE;SCHEMBL9385964;HIOYFEFCRFREPP-UHFFFAOYSA-N;CS-0370467;EN300-800010;G65536

Suppliers and Price of 5-Methoxy-2-(trifluoromethyl)aniline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 5-Methoxy-2-(trifluoromethyl)aniline

Chemical Property:

XLogP3:2.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:1
Exact Mass:191.05579836
Heavy Atom Count:13
Complexity:171

Purity/Quality:: 98%+ ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC(=C(C=C1)C(F)(F)F)N

Technology Process of 5-Methoxy-2-(trifluoromethyl)aniline

There total 4 articles about 5-Methoxy-2-(trifluoromethyl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 25889-37-6
4-methoxy-2-nitro-1-(trifluoromethyl)benzene

: 654-83-1
5-methoxy-2-(trifluoromethyl)aniline

Guidance literature:: 4-methoxy-2-nitro-1-(trifluoromethyl)benzene; With palladium 10% on activated carbon; hydrogen; In ethyl acetate; for 0.25h;

With palladium(II) hydroxide; In ethanol; for 5h;

Reference yield: 23.0%

: 887144-94-7
Togni's reagent II

: 536-90-3,918666-97-4
m-Anisidine

: 654-83-1
5-methoxy-2-(trifluoromethyl)aniline

: 106877-20-7
3-methoxy-4-(trifluoromethyl)aniline

: 53982-03-9
3-methoxy-2-(trifluoromethyl)aniline

Guidance literature:: With potassium carbonate; nickel(II) hydroxide; In dimethyl sulfoxide; at 35 ℃; for 2h; Inert atmosphere;
DOI:10.1021/acs.orglett.8b01216

Reference yield: 21.0%

: 75-63-8
Bromotrifluoromethane

: 536-90-3,918666-97-4
m-Anisidine

: 654-83-1
5-methoxy-2-(trifluoromethyl)aniline

: 106877-20-7
3-methoxy-4-(trifluoromethyl)aniline

: 53982-03-9
3-methoxy-2-(trifluoromethyl)aniline

: 106877-19-4
3-methoxy-2,6-bis(trifluoromethyl)aniline

Guidance literature:: With α-picoline; sodium metabisulfite; sulfur dioxide; zinc; In N,N-dimethyl-formamide; at 65 ℃; for 2h; under 2250.2 - 3750.3 Torr;