654059-02-6Relevant articles and documents
3-[4-(Methylsulfonyl)phenyl]-5-(trifluoromethyl)(2-pyridyl) phenyl ketone as a potent and orally active cyclooxygenase-2 selective inhibitor: Synthesis and biological evaluation
Khanapure, Subhash P.,Augustyniak, Michael E.,Earl, Richard A.,Garvey, David S.,Letts, L. Gordon,Martino, Allison M.,Murty, Madhavi G.,Schwalb, David J.,Shumway, Matthew J.,Trocha, Andrzej M.,Young, Delano V.,Zemtseva, Irina S.,Janero, David R.
, p. 3930 - 3934 (2005)
Incorporation of a spacer group between the central scaffold and the aryl ring resulted in a new cyclooxygenase-2 (COX-2) selective inhibitor core structure, 3-[4-(methylsulfonyl)phenyl]-5-(trifluoromethyl)(2-pyridyl) phenyl ketone (20), with COX-2 ICsub