654069-55-3

Usage

Class

Triazine compounds

Structure

Triazine ring with an ethyl and hydroxy group attached, and a phenyl group

Uses

a. Synthesis of various organic compounds
b. Building block in the production of pharmaceuticals, agrochemicals, and dyes
c. Potential applications in the development of new materials
d. Component in research and development activities

Safety precautions

Handle and store with care to prevent hazardous situations due to chemical properties and potential reactivity

Upstream product

• 74-96-4 ethyl bromide 
• 33859-68-6 6-Phenyl-1,2,4-triazine N-oxide 
• 925-90-6 ethylmagnesium bromide 

Relevant academic research and scientific papers

Regioselectivity of nucleophilic attack on the reactions of 1,2,4-triazine 4-oxides with certain C-nucleophiles

The addition of CH-active compounds to 6-aryl-1,2,4-triazine 4-oxide is reversible and occurs under conditions of kinetic control at position 5 of the heterocycle to form cyclic C(5)-σH adducts. Under conditions of thermodynamic control the nuc

Aromatic nucleophilic substitution in 1,2,4-triazine 4-oxides with Grignard reagents

Addition of the Grignard reagents to 1,2,4-triazine 4-oxides followed by aromatization of the intermediate σH-adducts by dehydrogenation or dehydration was used for synthesis of 5-alkyl- or 5-aryl-substituted 1,2,4-triazines and their 4-oxides.