654072-59-0Relevant academic research and scientific papers
Discovery and evaluation of a novel monocyclic series of CXCR2 antagonists
Austin, Rupert P.,Bennion, Colin,Bonnert, Roger V.,Cheema, Lal,Cook, Anthony R.,Cox, Rhona J.,Ebden, Mark R.,Gaw, Alasdair,Grime, Ken,Meghani, Premji,Nicholls, David,Phillips, Caroline,Smith, Neal,Steele, John,Stonehouse, Jeffrey P.
, p. 1616 - 1620 (2015)
Antagonism of the chemokine receptor CXCR2 has been proposed as a strategy for the treatment of inflammatory diseases such as arthritis, chronic obstructive pulmonary disease and asthma. Earlier series of bicyclic CXCR2 antagonists discovered at AstraZene
PYRIMIDYL SULPHONE AMIDE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS
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, (2008/06/13)
A compound of formula (I), pharmaceutically acceptable salt, solvate or in vivo hydrolysable ester thereof for the treatment of asthma, allergic rhinitis, COPD, inflammatory bowel disease, irritable bowel syndrome, osteoarthritis, osteoporosis, rheumatoid
