65416-29-7Relevant academic research and scientific papers
Liquid-Liquid Extraction Protocol for the Removal of Aldehydes and Highly Reactive Ketones from Mixtures
Boucher, Maria M.,Furigay, Maxwell H.,Quach, Phong K.,Brindle, Cheyenne S.
, p. 1394 - 1403 (2017/09/23)
The reaction of the bisulfite ion with aldehydes to form charged bisulfite adducts is a well-established method for the purification of aldehydes. This reaction has been modified to create a convenient liquid-liquid extraction method for the removal of aldehydes from mixtures. The use of a water-miscible solvent allows the reaction to occur during a simple 30 s shaking protocol by increasing the contact between the bisulfite ion and the aldehyde. The introduction of an immiscible solvent allows for the extraction of the uncharged organic components away from the bisulfite adduct. The developed protocol is applicable to a wide range of aldehydes, including sterically hindered neopentyl aldehydes. Sterically unhindered cyclic and linear ketones, as well as highly electrophilic ketones, are also removed using this protocol. The mild conditions tolerate a wide range of functional groups, allowing for excellent aldehyde contaminant removal rates with high levels of recovery of the desired component.
Direct reductive alkylation of amine hydrochlorides with aldehyde bisulfite adducts
Barniol-Xicota, Marta,Turcu, Andreea L.,Codony, Sandra,Escolano, Carmen,Vázquez, Santiago
supporting information, p. 2548 - 2550 (2014/05/06)
A mild procedure for the direct reaction of aromatic and aliphatic aldehyde bisulfite adducts with primary and secondary amine hydrochlorides in the presence of sodium cyanoborohydride in methanol is reported.
A NOVEL AND VERSATILE SEPARATION METHOD FOR ALDEHYDES
Ohta, Shunsaku,Okamoto, Masao
, p. 1917 - 1919 (2007/10/02)
An aqueous solution of sodium ε-amino-n-caproate can be used for efficient and simple separation of aldehydes, overcoming the difficulties associated with the NaHSO3 method.Keywords - separation of aldehydes; Schiff base of amino acid; ω-amino acid; sodium ε-amino-n-caproate; sodium bisulfite adduct of aldehydes
