65446-24-4

Usage

Uses

Used in Biochemical Research:
2-Chloro-4-nitrophenyl-α-D-mannopyranoside is used as a synthetic substrate for studying the enzyme activity of α-mannosidases, which are crucial in the breakdown of complex carbohydrates. Its application is instrumental in understanding the role and function of these enzymes in biological processes.
Used in Enzyme Inhibition Studies:
In the field of enzyme research, 2-Chloro-4-nitrophenyl-α-D-mannopyranoside is utilized as a specific inhibitor of the enzyme α-mannosidase. This allows researchers to investigate the effects of inhibiting this enzyme on various biological systems and pathways, providing insights into the enzyme's role in health and disease.
Used in Microbiological Research:
2-Chloro-4-nitrophenyl-α-D-mannopyranoside is also employed in microbiological studies to examine the interaction of α-mannosidases with microorganisms, particularly in the context of pathogenicity and host-pathogen interactions. This helps in understanding the mechanisms of microbial infections and the development of potential therapeutic strategies.
Used in Drug Development:
2-Chloro-4-nitrophenyl-a-D-mannopyranoside is used in the development of drugs targeting α-mannosidase activity, which may have therapeutic applications in conditions related to carbohydrate metabolism disorders or in modulating immune responses. Its specificity makes it a useful probe in the design and testing of new pharmaceutical agents.

Upstream product

• 153823-58-6 2-chloro-4-nitrophenyl 2,3,4,6-tetra-O-acetyl-α-D-mannopyranoside 
• 619-08-9 2-chloro-4-nitrophenol 
• 4163-65-9 per-O-acetyl-α-D-mannopyranose 

Downstream Products

• 1403988-92-0 4-amino-2-chlorophenyl α-D-mannopyranoside 
• 1403988-91-9 2-chloro-4-[(2-(4-methylpiperazin-1-yl)-3,4-dioxocyclobuten-1-yl)amino]phenyl α-D-mannopyranoside 
• 916849-17-7 o-chloro-p-[N-(2-ethoxy-3,4-dioxocyclobut-1-enyl)amino]phenyl α-D-mannopyranoside 

Relevant academic research and scientific papers

Binuclear copper(II) complexes discriminating epimeric glycosides and α- And β-glycosidic bonds in aqueous solution

Two chiral binuclear copper(II) complexes were synthesized and characterized for the first time as efficient chemoselective catalysts for the hydrolysis of aryl glycosides and disaccharides in aqueous solution at near neutral pH. Under these conditions, discrimination of epimeric aryl α-glycopyranosides was observed by both 29-fold different reaction rates and 3-fold different proficiency of the catalyst. Additionally, large differentiation of the nature of α- and β-glycosidic bond in aryl glycosides as model compounds is apparent, but also noted in selected disaccharides. The influence of the chirality of the complexes and the role of the configuration of the carbohydrate upon interaction with the catalyst is discussed in detail. Lastly, a putative mechanism for the metal complex-catalyzed hydrolysis is derived from the experimental evidence pointing at deprotonation of the hydroxyl group at C-2 as a pre-requisite for glycoside hydrolysis.