65452-76-8

Upstream product

• 104-87-0 4-methyl-benzaldehyde 
• 539-44-6 N-4-methylphenylhydrazine 
• 106-49-0 p-toluidine 
• 637-60-5 p-tolylhydrazine hydrochloride 

Downstream Products

• 53811-77-1 1-benzyl-5-methyl-2-(4-methylphenyl)-1H-benzimidazole 
• 213965-86-7 1-(4-methylbenzylidene)-2-benzyl-2-p-tolylhydrazine 
• 1601316-26-0 4-(3-chloro-4-methylphenyl)-2,5-di(4-methylphenyl)-2H-1,2,4-triazol-3(4H)-one 
• 1601316-34-0 4-phenyl-2,5-di(4-methylphenyl)-2H-1,2,4-triazol-3(4H)-one 

Relevant academic research and scientific papers

Acid-Mediated Three Component Assembly of 4-Fluoropyrazoles from α-Fluoronitroalkenes, Hydrazines, and Aldehydes

A new approach for the synthesis of highly pharmaceutically relevant 4-fluoropyrazoles via oxidative annulation of α-fluoronitroalkenes with in situ prepared hydrazones was developed. The reaction is efficiently promoted by trifluoroacetic acid while atmo

Facile synthesis of pyrazoles by iron-catalyzed regioselective cyclization of hydrazone and 1,2-diol under ligand-free conditions

A facile synthesis of pyrazoles by the cyclization of hydrazones and 1,2-diols was described. In the presence of ferric nitrate, the reaction occurs under neat conditions and makes the use of potassium persulfate to oxidize the diol to α-hydroxy carbaldehyde for the reaction with hydrazones to produce 1,3- and 1,3,5-substituted pyrazoles selectively. The overall regioselective transformation occurs in one-pot under ligand-free, mild conditions even in the presence of air.

Microwave assisted one-pot tandem three-component synthesis of 2,4,5-triary1-2-4-dihydro-3H-1,2,4-triazol-3-one derivatives

This work described a one-pot tandem three-component synthesis of 2,4,5-triaryl-2,4-dihydro-3H-1,2,4-triazol-3-ones using a simple reaction between phenylhydrazines, benzaldehydes and phenyl isocyanates under microwave irradiation and solvent-free conditi

Copper-mediated synthesis of substituted 2-aryl-N-benzylbenzimidazoles and 2-arylbenzoxazoles via C-H functionalization/C-N/C-O bond formation

An efficient method for the transformation of N-benzyl bisarylhydrazones and bisaryloxime ethers to functionalized 2-aryl-N-benzylbenzimidazoles and 2-arylbenzoxazoles is described. The protocol involves a copper(II)-mediated cascade C-H functionalization/C-N/C-O bond formation under neutral conditions. Substrates having either electron-donating or -withdrawing substituents undergo the cyclization to afford the target heterocycles at moderate temperature.