654635-34-4Relevant academic research and scientific papers
Synthesis and hydrazinolysis of β-(1,3,4-oxadiazol-2-yl)pyridines
Nesterova,Pugachova,Voevudsky,Krischik,Musatov
, p. 1520 - 1526 (2011)
Cyclization of the hydrazide of 5-ethoxycarbonyl-2,6-dimethylpyridine-3- carboxylic acid by acylation with aromatic or aliphatic acid chlorides with subsequent boiling in POCl3 or heating in orthoformic acid gave the corresponding ethyl 2,6-dimethyl-5-(5-R-1,3,4-oxadiazol-2-yl)pyridine-3- carboxylate. The cyclization of the reaction products with hydrazine hydrate has been studied. Cyclization of the dihydrazide of 2,6-dimethyl-3,5- pyridinedicarboxylic acid under analogous conditions gave only 3,5-bis-(5-R-1,3,4-oxadiazol-2-yl)-2,6-dimethylpyridines, containing R = 2-FC6H4, H.
