654674-77-8

Upstream product

• 403-42-9 1-(4-fluorophenyl)ethanone 
• 35856-62-3 1-piperidinesulfonyl chloride 
• 58518-77-7 ((1-(4-fluorophenyl)vinyl)oxy)trimethylsilane 

Relevant academic research and scientific papers

Photoredox-Catalyzed Generation of Sulfamyl Radicals: Sulfonamidation of Enol Silyl Ether with Chlorosulfonamide

A novel and practical photoredox-catalyzed generation of sulfamyl radicals followed by radical sulfonamidation of enol silyl ether has been described. Diverse functionalized β-ketosulfonamides were prepared in modest to excellent yields under mild and economic reaction conditions through the present catalytic protocol. Furthermore, the methodology developed provides an efficient and convenient approach to the synthesis of the antiseizure drug Zonisamide.

CHEMICAL COMPOUNDS

Compounds of formula (I):wherein variable groups are as defined within; for use in the inhibition of 11betaHSD1 are described