654678-28-1

Basic information

• Product Name: 1-Propanone, 1,2-diphenyl-3-(3-pyridinyl)-
• CAS NO: 654678-28-1
• Molecular Formula: C20H17NO
• Molecular Weight: 287.361
• Mol File: 654678-28-1.mol

Chemical Properties

• CAS DataBase Reference: 1-Propanone, 1,2-diphenyl-3-(3-pyridinyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Propanone, 1,2-diphenyl-3-(3-pyridinyl)-(654678-28-1)
• EPA Substance Registry System: 1-Propanone, 1,2-diphenyl-3-(3-pyridinyl)-(654678-28-1)

Safety Data

• Hazardous Substances Data: 654678-28-1(Hazardous Substances Data)

Upstream product

• 451-40-1 phenyl benzyl ketone 
• 100-55-0 3-hydroxymethylpyridin 

Relevant articles and documents

NNN pincer Ru(II)-complex-catalyzed α-alkylation of ketones with alcohols

A series of novel ruthenium(II) complexes supported by a symmetrical NNN ligand were prepared and fully characterized. These complexes exhibited good performance in transfer hydrogenation to form new C-C bonds using alcohols as the alkylating agents, generating water as the only byproduct. A broad range of substrates, including (hetero)aryl- or alkyl-ketones and alcohols, were well tolerated under the optimized conditions. Notably, α-substituted methylene ketones were also investigated, which afforded α-branched steric hindrance products. A potential application of α-alkylation of methylene acetone to synthesize donepezil was demonstrated, which provided the desired product in 83% yield. Finally, this catalytic system could be applied to a one-pot double alkylation procedure with sequential addition of two different alcohols. The current protocol is featured with several characteristics, including a broad substrate scope, low catalyst (0.50 mol %) loadings, and environmental benignity.

CHEMICAL COMPOUNDS

Compounds of formula (I):wherein variable groups are as defined within; for use in the inhibition of 11betaHSD1 are described