6547-34-8Relevant academic research and scientific papers
Biomimetic synthesis of the calcineurin phosphatase inhibitor dibefurin
Ellerbrock, Pascal,Armanino, Nicolas,Trauner, Dirk
supporting information, p. 13414 - 13418 (2015/02/05)
Dibefurin is a Ci-symmetric natural product that acts as an inhibitor of calcineurin phosphatase. A six-step synthesis of this compound is reported, which features an oxidative dimerization of the aromatic polyketide epicoccine as the key step. Dibefurin is proposed to be related to epicolactone, a complex yet racemic fungal metabolite that has recently been discovered. Attempts to access epicolactone from epicoccine and epicoccone B resulted in an unusual dimer that is formed through a hetero-Diels-Alder reaction of a para-quinone methide with an ortho-quinone.
The Oxidation of a Series of Phthalyl Alcohols
Bhattacharjee, Debkumar,Popp, Frank D.
, p. 315 - 320 (2007/10/02)
A series of phthalyl alcohols containing methoxy and methyl substituents were prepared by lithium aluminum hydride reduction of phthalides.Oxidation of the phthalyl alcohols with activated manganese dioxide or with barium manganate gave phthalaldehydes or
