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65476-32-6

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65476-32-6 Usage

General Description

(4-hydrazinophenyl)acetic acid hydrochloride is a chemical compound that consists of a hydrazine group attached to a phenylacetic acid molecule, with a hydrochloride salt. (4-hydrazinophenyl)acetic acid hydrochloride is commonly used in the synthesis of various organic compounds and pharmaceuticals due to its versatile reactivity and functional groups. It can also act as a building block for the preparation of hydrazono-1,2,3-triazole derivatives, and as a ligand for transition-metal-catalyzed reactions. Additionally, it has potential applications in medicinal chemistry and research as a tool for the development of new drugs and biologically active compounds. However, it is important to handle this compound with care, as it may have toxic or hazardous properties.

Check Digit Verification of cas no

The CAS Registry Mumber 65476-32-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,5,4,7 and 6 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 65476-32:
(7*6)+(6*5)+(5*4)+(4*7)+(3*6)+(2*3)+(1*2)=146
146 % 10 = 6
So 65476-32-6 is a valid CAS Registry Number.
InChI:InChI=1/C8H10N2O2/c9-10-7-3-1-6(2-4-7)5-8(11)12/h1-4,10H,5,9H2,(H,11,12)

65476-32-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-(4-hydrazinylphenyl)acetic acid,hydrochloride

1.2 Other means of identification

Product number -
Other names p-carboxymethylphenylhydrazine hydrochloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:65476-32-6 SDS

65476-32-6Upstream product

65476-32-6Relevant articles and documents

NEAR-IR GLUCOSE SENSORS

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Paragraph 0550-0551, (2020/01/22)

Glucose-sensing luminescent dyes, polymers, and sensors are provided. Additionally, systems including the sensors and methods of using these sensors and systems are provided.

NEAR-IR GLUCOSE SENSORS

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Paragraph 0351; 0352, (2018/07/15)

Glucose-sensing luminescent dyes, polymers, and sensors are provided. Additionally, systems including the sensors and methods of using these sensors and systems are provided.

Structure-based design, synthesis and biological evaluation of N-pyrazole, N′-thiazole urea inhibitors of MAP kinase p38α

Getlik, Matth?us,Grütter, Christian,Simard, Jeffrey R.,Nguyen, Hoang D.,Robubi, Armin,Aust, Beate,Van Otterlo, Willem A.L.,Rauh, Daniel

experimental part, p. 1 - 15 (2012/03/26)

In this paper, we present the structure-based design, synthesis and biological activity of N-pyrazole, N′-thiazole-ureas as potent inhibitors of p38α mitogen-activated protein kinase (p38α MAPK). Guided by complex crystal structures, we employed the initially identified N-aryl, N′-thiazole urea scaffold and introduced key structural elements that allowed the formation of novel hydrogen bonding interactions within the allosteric site of p38α, resulting in potent type III inhibitors. [4-(3-tert-Butyl-5-{[(1,3-thiazol-2-ylamino)carbonyl]amino}-1H-pyrazol-1-yl) -phenyl]acetic acid 18c was found to be the most potent compound within this series and inhibited p38α activity with an IC50 of 135 ± 21 nM. Its closest analog, ethyl [4-(3-tert-butyl-5-{[(1,3-thiazol-2-ylamino) carbonyl]amino}-1H-pyrazol-1-yl)phenyl]acetate 18b, effectively inhibited p38α mediated phosphorylation of the mitogen activated protein kinase activated protein kinase 2 (MK2) in HeLa cells.

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