65482-79-3Relevant academic research and scientific papers
Pentafluorophenyl Esters: Highly Chemoselective Ketyl Precursors for the Synthesis of α,α-Dideuterio Alcohols Using SmI2 and D2O as a Deuterium Source
Li, Hengzhao,Hou, Yuxia,Liu, Chengwei,Lai, Zemin,Ning, Lei,Szostak, Roman,Szostak, Michal,An, Jie
, p. 1249 - 1253 (2020)
We report the first highly chemoselective synthesis of α,α-dideuterio alcohols with exquisite incorporation of deuterium (>98% [D2]) using pentafluorophenyl esters as ketyl radical precursors, SmI2 as a mild reducing agent, and Dsub
Pharmacokinetic profile of atenolol aspirinate
Montes-Gil, Ana C.,Zanfolin, Marcos,Okuyama, Cristina E.,Lilla, Sergio,Alves, Delma P.,Santagada, Vincenzo,Perissutti, Elisa,Lavecchia, Antonio,Fiorino, Ferdinando,Severino, Beatrice,Caliendo, Giuseppe,Priviero, Fernanda B. M.,Mendes, Gustavo D.,Donato, Jose L.,De Nucci, Gilberto
, p. 445 - 455 (2008/12/21)
We report microwave-assisted synthetic routes, the pharmacokinetic profile along with results from ulcerogenicity and mutagenicity studies of atenolol aspirinate, and an already described derivative, in which acetyl salicylic acid (aspirin) was connected to atenolol by an ester linkage. Atenolol aspirinate was stable towards aqueous hydrolysis but rapidly hydrolyzed in plasma (t1/2 = 7.6 min). The results showed that the rapid and complete hydrolysis generates atenolol salicylate, which assumes a conformation stabilized by two intramolecular H-bonds, avoiding its further hydrolysis to salicylic acid and atenolol.
