65492-82-2

Basic information

• Product Name: edelfosine
• CAS NO: 65492-82-2
• Molecular Formula: C27H58NO6P
• Molecular Weight: 523.726281
• Mol File: 65492-82-2.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: edelfosine(CAS DataBase Reference)
• NIST Chemistry Reference: edelfosine(65492-82-2)
• EPA Substance Registry System: edelfosine(65492-82-2)

Safety Data

• Hazardous Substances Data: 65492-82-2(Hazardous Substances Data)

Usage

Description

Edelfosine is a synthetic alkyl-lysophospholipid derivative with promising potential as an anti-cancer agent. It is known to induce apoptosis in various cancer cell lines, particularly in leukemia and solid tumors. Edelfosine also exhibits potential anti-microbial, anti-viral, and anti-inflammatory properties. Its mechanism of action involves the disruption of lipid rafts and the activation of signaling pathways involved in apoptosis. Ongoing research is exploring its use in cancer treatment and as a potential therapeutic agent for other conditions.

Uses

Used in Cancer Treatment:
Edelfosine is used as an anti-cancer agent for its ability to induce apoptosis in various cancer cell lines, including leukemia and solid tumors. It modulates lipid rafts and activates apoptosis-related signaling pathways, making it a promising candidate for cancer therapy.
Used in Pharmaceutical Research:
Edelfosine is used as a research compound for investigating its potential anti-microbial, anti-viral, and anti-inflammatory properties. Its mechanism of action through lipid raft disruption and apoptosis signaling activation provides a foundation for exploring its therapeutic potential in various conditions beyond cancer treatment.

InChI:InChI=1/C27H58NO6P/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-23-32-25-27(31-5)26-34-35(29,30)33-24-22-28(2,3)4/h27H,6-26H2,1-5H3/p+1

Upstream product

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Relevant articles and documents

Trimethylsilyl triflate mediated introduction of phospholipid head groups

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D and L etherlipid stereoisomers and liposomes

A liposome having a lipid bilayer, where the lipid bilayer includes either the L or D stereoisomer of an ether lipid or a non-equal mixture of both. Most preferably the liposome also comprises (a) an underivatized phosphatidylcholine; (b) a sterol; (c) about 5-20 mole % of a phosphatidylethanolamine linked to a dicarboxylic acid at the ethanolamine group of the phosphatidylethanolamine, and (d) greater than about 10 mole % to less than about 30 mole % of either the L or D stereoisomer of an ether lipid. The liposome may be used as an anti-cancer or anti-inflammatory agent.

Chiral PAF agonists: Synthesis, theoretical analysis of their stereoelectronic properties and structure activity relationships

A series of chiral PAF agonists were synthesized. Modifications at the PAF structure were undertaken as far as the C2 substituents and the onium head groups are concerned. In parallel, molecular modelling studies including a MOPAC geometry optimization and the analysis of the electrostatic potential were performed on the newly synthesized and on already known PAF agonists, in order to gain a better insight into the stereoelectronic features required for interaction with the PAF receptor.