65499-26-5

Upstream product

• 135520-65-9 C₁₀H₁₅NO₃ 
• 135520-60-4 8-oxo-oct-2-ynoic acid methyl ester 
• 65499-33-4 methyl 2-(1-hydroxycyclohexyl)-2,2-dimethoxyacetate 
• 99334-06-2 rac-2-cyclohexenyl-2-hydroxyethanoic acid methyl ester 

Downstream Products

• 137313-10-1 methyl α-(2-benzylthiocyclohexyl)-α-oxoacetate 
• 1224978-80-6 (R)-methyl 2-cyano-2-(cyclohexen-1-yl)-2-trimethylsiloxyacetate 

Relevant academic research and scientific papers

3-Hydroxy-2-oxo-1-oxaspiro[4.5]-dec-3-ene, a new inhibitor of lactate dehydrogenase

Methods for the synthesis of the spirolactone [3-hydroxy-2-oxo-1-oxaspiro[4.5]-dec-3-ene, 3] and the sodium salts of two new α-keto acids [(1-cyclohexenyl)glyoxylate 1, β-(1-hydroxycyclohexane)pyruvate (enol form, 2)] are described. These compounds are ex

Synthesis and biological activity of new C-6 and C-7 substituted vinyloxyimino-penicillins and -cephalosporins

The Wittig reaction has been successfully utilized in the preparation of a number of substituted α-vinyloxyiminoacetic acids, the subsequent coupling of which to the 6-APA and 7-ACA nuclei has provided a range of potent β-lactam antibiotics.Development of other procedures for olefin synthesis has broadened the scope, with the preparation of a range of alkenyl-, cycloalkenyl- and arylvinyl-oxyiminoacetamidopenicillins and cephalosporins.

INTRAMOLECULAR NITRONE-ALKYNE CYCLOADDITION

It is demonstrated that the cycloaddition of a nitrone to an alkyne is facile when the length of the tether connecting the two reacting sites is appropriate.The resulting cycloaddition products, isoxazolidines can be further converted to 3-hyd