65499-40-3

Basic information

• Product Name: Triacetyl Uridine
• Synonyms: Triacetyl Uridine
• CAS NO: 65499-40-3
• Molecular Formula: C₁₅H₁₇IN₂O₉
• Molecular Weight: 370.31142
• Mol File: 65499-40-3.mol
• Article Data: 26

Chemical Properties

• Melting Point: 168 °C
• Appearance: /
• Density: 1.79±0.1 g/cm3(Predicted)
• PKA: 7.94±0.10(Predicted)
• CAS DataBase Reference: Triacetyl Uridine(CAS DataBase Reference)
• NIST Chemistry Reference: Triacetyl Uridine(65499-40-3)
• EPA Substance Registry System: Triacetyl Uridine(65499-40-3)

Safety Data

• Hazardous Substances Data: 65499-40-3(Hazardous Substances Data)

Usage

General Description

Triacetyl Uridine is a derivative of the nucleoside uridine, modified with three acetyl groups. It is a synthetic compound with potential therapeutic uses, particularly in the field of pharmaceuticals. Triacetyl Uridine has been studied for its potential to enhance cognitive function and memory, as well as its neuroprotective effects. Research has shown that it may have potential in treating neurodegenerative diseases and age-related cognitive decline. In addition, Triacetyl Uridine has been explored for its potential role in promoting cell growth and repair, making it of interest in the field of regenerative medicine. Overall, Triacetyl Uridine is a compound with promising potential for a variety of applications in health and medicine.

Upstream product

• 58-96-8 uridine 
• 696-07-1 5-iodouracil 
• 13035-61-5 1,2,3,5-tetraacetylribose 
• 65-46-3 CYTIDINE 
• 5040-18-6 4-N-2',3',5'-O-tetraacetylcytidine 
• 38953-72-9 5-iodo-2,4-bis-O-trimethylsilyluracil 
• 1024-99-3 5-iodouridine 
• 108-24-7 acetic anhydride 
• 4105-38-8 Tri-O-acetyluridine 

Downstream Products

• 65499-41-4 2',3',5'-tri-O-acetyl-5-(trifluoromethyl)uridine 
• 174193-14-7 Acetic acid (2R,3R,4R,5R)-4-acetoxy-5-acetoxymethyl-2-{2,4-dioxo-5-[3-(tetrahydro-pyran-2-yloxy)-prop-1-ynyl]-3,4-dihydro-2H-pyrimidin-1-yl}-tetrahydro-furan-3-yl ester 
• 209254-91-1 Acetic acid (2R,3R,4R,5R)-4-acetoxy-5-acetoxymethyl-2-[5-(6-ethynyl-dibenzofuran-4-ylethynyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl ester 
• 1070900-54-7 C₂₆H₃₂N₃O₁₀ 
• 69075-42-9 5-ethynyluridine 
• 1428477-12-6 2’-O-tert-butyldimethylsilyl-5-ethinyl uridine 
• 1428477-07-9 2’-O-tert-butyldimethylsilyl-3‘,5‘-O-bis(tert-butyl)silyl-5-ethinyl uridine 
• 1428477-08-0 2’-O-tert-butyldimethylsilyl-3’,5’-O,O-bis[di(2-cyanoethyl)]phosphoryl-5-ethinyl uridine 
• 1428477-09-1 C₁₁H₁₄N₂O₁₂P₂ 
• 139323-52-7 N-trit-U-morpholino 
• 109205-43-8 2-(2,4-dioxo-4,4-dihydropyrimidin-1(2H)-yl)-6-(hydroxymethyl)morpholine 

Relevant articles and documents

Design, synthesis, and biological evaluation of novel C5-modified pyrimidine ribofuranonucleosides as potential antitumor or/and antiviral agents

Background: Nucleoside analogues are well-known antitumor, antiviral, and chemotherapeutic agents. Alterations on both their sugar and the heterocyclic parts may lead to significant changes in the spectrum of their biological activity and the degree of selective toxicity, as well as in their physicochemical properties. Method: C5-arylalkynyl-β-D-ribofuranonucleosides 3-6, 3?-deoxy 12-15, 3?-deoxy-3?-C-methyl-β-D-ribofurananucleosides 18-21 and 2?-deoxy-β-D-ribofuranonucleosides 23-26 of uracil, were synthesized using a one-step Sonogashira reaction under microwave irradiation and subsequent deprotection. Results: All newly synthesized nucleosides were tested for their antitumor or antiviral activity. Moderate cytostatic activity against cervix carcinoma (HeLa), murine leukemia (L1210) and human lymphocyte (CEM) tumor cell lines was displayed by the protected 3?-deoxy derivatives 12b, 12c, 12d, and the 3?-deoxy-3?-methyl 18a, 18b, 18c. The antiviral evaluation revealed appreciable activity against Coxsackie virus B4, Respiratory syncytial virus, Yellow Fever Virus and Human Coronavirus (229E) for the 3?-deoxy compounds 12b, 14, and the 3?-deoxy-3?-methyl 18a, 18c, 18d, accompanied by low cytotoxicity. Conclusion: This report describes the total and facile synthesis of modified furanononucleosides of uracil, with alterations on both the sugar and the heterocyclic portions. Compounds 12b, 14 and 18a,c,d showed noticeable antiviral activity against a series of RNA viruses and merit further biological and structural optimization investigations.

Effective Synthesis of 5-Iodo Derivatives of Pyrimidine Morpholino Nucleosides

-

A solid-supported acidic oxazolium perchlorate as an easy-handling catalyst for the synthesis of modified pyrimidine nucleosides via Vorbrüggen-type N-glycosylation

A solid-supported acidic oxazolium perchlorate was investigated as a heterogeneous catalyst in N-glycosylation reactions using silylated modified pyrimidines and an acylated ribose or glucose to afford the corresponding pyrimidine nucleosides. This salt is a nonhygroscopic and stable powder whose activity is comparable to that of 2-methyl-5-phenylbenzoxazolium perchlorate. A reaction with this polymer catalyst can be conducted on a gram scale. Reusability of the solid-supported catalyst was also investigated.