655-78-7

Basic information

• Product Name: Acetamide, N-[4-[[(3-methoxypyrazinyl)amino]sulfonyl]phenyl]-
• CAS NO: 655-78-7
• Molecular Formula: C13H14N4O4S
• Molecular Weight: 322.345
• Mol File: 655-78-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Acetamide, N-[4-[[(3-methoxypyrazinyl)amino]sulfonyl]phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, N-[4-[[(3-methoxypyrazinyl)amino]sulfonyl]phenyl]-(655-78-7)
• EPA Substance Registry System: Acetamide, N-[4-[[(3-methoxypyrazinyl)amino]sulfonyl]phenyl]-(655-78-7)

Safety Data

• Hazardous Substances Data: 655-78-7(Hazardous Substances Data)

Upstream product

• 4774-10-1 2-amino-3-methoxypyrazine 
• 121-60-8 p-acetylaminobenzenesulfonyl chloride 

Downstream Products

• 152-47-6 Sulfalen 
• 1360614-48-7 (2E)-N-[4-[[(3-methoxy-2-pyrazinyl)amino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-2-propenamide 
• 1384274-37-6 (E)-N-(4-(N-(3-methoxypyrazin-2-yl)sulfamoyl)phenyl)-3-(thiophen-2-yl)acrylamide 
• 1384274-35-4 N-(4-(N-(3-methoxypyrazin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophen-2-yl)propanamide 
• 1384274-36-5 N-(4-(N-(3-methoxypyrazin-2-yl)sulfamoyl)phenyl)-3-(thiophen-2-yl)propanamide 
• 1384274-28-5 (E)-3-(5-bromothiophen-2-yl)-N-(4-(N-(3-methoxypyrazin-2-yl)sulfamoyl)phenyl)acrylamide 
• 1384274-31-0 (E)-N-(4-(N-(3-methoxypyrazin-2-yl)sulfamoyl)phenyl)-3-(3-nitrophenyl)acrylamide 
• 1384274-29-6 (E)-N-(4-(N-(3-methoxypyrazin-2-yl)sulfamoyl)phenyl)-3-(4-nitrophenyl)acrylamide 

Relevant articles and documents

Necrosulfonamide inhibits necroptosis by selectively targeting the mixed lineage kinase domain-like protein

Through high-throughput screening of 200000 compounds and subsequent structure-activity relationship (SAR) studies we identified necrosulfonamide (NSA) as a potent small molecule inhibitor for necroptosis, induced by a combination of TNF-a, Smac mimetic, and z-VAD-fmk (T/S/Z). Applying a forward chemical genetic approach, we utilized an NSA based chemical probe to further reveal that NSA selectively targeted the Mixed Lineage Kinase Domain-like Protein (MLKL) to block the necrosome formation.