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2-AMINO-3-METHOXYPYRAZINE is a heterocyclic chemical compound with the molecular formula C5H8N2O, belonging to the class of pyrazines. It is known for its distinct earthy, musty, and roasted odor, and is commonly found in food products such as roasted coffee, cocoa, and cooked meats, where it contributes to their aroma and flavor.

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  • 4774-10-1 Structure
  • Basic information

    1. Product Name: 2-AMINO-3-METHOXYPYRAZINE
    2. Synonyms: 2-AMINO-3-METHOXYPYRAZINE;3-METHOXYPYRAZIN-2-YLAMINE;3-methoxypyrazin-2-amine;3-Methoxy-2-pyrazinamine
    3. CAS NO:4774-10-1
    4. Molecular Formula: C5H7N3O
    5. Molecular Weight: 125.13
    6. EINECS: N/A
    7. Product Categories: Amines;Pyrazines, Pyrimidines & Pyridazines;Pyrazines, Pyrimidines & Pyridazines
    8. Mol File: 4774-10-1.mol
  • Chemical Properties

    1. Melting Point: 84-85℃
    2. Boiling Point: 241℃
    3. Flash Point: 100℃
    4. Appearance: /
    5. Density: 1.224
    6. Vapor Pressure: 0.037mmHg at 25°C
    7. Refractive Index: 1.567
    8. Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
    9. Solubility: N/A
    10. PKA: 3.49±0.10(Predicted)
    11. CAS DataBase Reference: 2-AMINO-3-METHOXYPYRAZINE(CAS DataBase Reference)
    12. NIST Chemistry Reference: 2-AMINO-3-METHOXYPYRAZINE(4774-10-1)
    13. EPA Substance Registry System: 2-AMINO-3-METHOXYPYRAZINE(4774-10-1)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: IRRITANT
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 4774-10-1(Hazardous Substances Data)

4774-10-1 Usage

Uses

Used in Food Industry:
2-AMINO-3-METHOXYPYRAZINE is used as a flavoring agent for its characteristic earthy, musty, and roasted notes, enhancing the aroma and taste of food products such as roasted coffee, cocoa, and cooked meats.
Used in Fragrance Industry:
2-AMINO-3-METHOXYPYRAZINE is used as a fragrance ingredient to impart earthy and roasted notes to perfumes and colognes, adding depth and complexity to the scent profile.
Used in Pharmaceutical Industry:
2-AMINO-3-METHOXYPYRAZINE has potential applications in the pharmaceutical industry, although specific uses are not detailed in the provided materials.
Used as a Chemical Intermediate:
2-AMINO-3-METHOXYPYRAZINE serves as a chemical intermediate in organic synthesis, contributing to the production of various chemical compounds and products.
Safety Note:
It is important to handle 2-AMINO-3-METHOXYPYRAZINE with caution, as it may have toxic effects if ingested or inhaled in high concentrations. Proper safety measures should be taken during its use and handling to minimize potential health risks.

Check Digit Verification of cas no

The CAS Registry Mumber 4774-10-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,7,7 and 4 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 4774-10:
(6*4)+(5*7)+(4*7)+(3*4)+(2*1)+(1*0)=101
101 % 10 = 1
So 4774-10-1 is a valid CAS Registry Number.
InChI:InChI=1/C5H7N3O/c1-9-5-4(6)7-2-3-8-5/h2-3H,1H3,(H2,6,7)

4774-10-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-Amino-3-methoxypyrazine

1.2 Other means of identification

Product number -
Other names 2-amino-3-methoxypyrazine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:4774-10-1 SDS

4774-10-1Relevant articles and documents

Discovery of AZD-2098 and AZD-1678, Two Potent and Bioavailable CCR4 Receptor Antagonists

Kindon, Nicholas,Andrews, Glen,Baxter, Andrew,Cheshire, David,Hemsley, Paul,Johnson, Timothy,Liu, Yu-Zhen,McGinnity, Dermot,McHale, Mark,Mete, Antonio,Reuberson, James,Roberts, Bryan,Steele, John,Teobald, Barry,Unitt, John,Vaughan, Deborah,Walters, Iain,Stocks, Michael J.

, p. 981 - 986 (2017)

N-(5-Bromo-3-methoxypyrazin-2-yl)-5-chlorothiophene-2-sulfonamide 1 was identified as a hit in a CCR4 receptor antagonist high-throughput screen (HTS) of a subset of the AstraZeneca compound bank. As a hit with a lead-like profile, it was an excellent sta

Necrosulfonamide inhibits necroptosis by selectively targeting the mixed lineage kinase domain-like protein

Liao, Daohong,Sun, Liming,Liu, Weilong,He, Sudan,Wang, Xiaodong,Lei, Xiaoguang

supporting information, p. 333 - 337 (2014/03/21)

Through high-throughput screening of 200000 compounds and subsequent structure-activity relationship (SAR) studies we identified necrosulfonamide (NSA) as a potent small molecule inhibitor for necroptosis, induced by a combination of TNF-a, Smac mimetic, and z-VAD-fmk (T/S/Z). Applying a forward chemical genetic approach, we utilized an NSA based chemical probe to further reveal that NSA selectively targeted the Mixed Lineage Kinase Domain-like Protein (MLKL) to block the necrosome formation.

Peptide deformylase inhibitors

-

Page/Page column, (2014/12/09)

The present invention relates to a compound of Formula (I): or a pharmaceutically acceptable salt thereof, corresponding pharmaceutical compositions, compound preparation and treatment methods directed to bacterial infections and inhibition of bacterial peptide deformylase (PDF) activity.

PEPTIDE DEFORMYLASE INHIBITORS

-

Page/Page column, (2014/02/15)

The present invention relates to a compound of Formula (I): or a pharmaceutically acceptable salt thereof, corresponding pharmaceutical compositions, compound preparation and treatment methods directed to bacterial infections and inhi-bition of bacterial peptide deformylase (PDF) activity

Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives

-

Page 123, (2008/06/13)

This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with azaindoleoxoacetyl piperazine derivatives. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS.

A new route to aminodiazines via metalation reaction. Synthesis of an aza analogue of Nevirapine: Diazines XV

Plé, Nelly,Turck, Alain,Couture, Karine,Quéguiner, Guy

, p. 838 - 842 (2007/10/03)

A new route to aminodiazines is reported, the ortho-directed lithiation of diazines is used, followed by reaction with tosyl azide as an electrophile. The reduction of the azido or tetrazolo compounds obtained was achieved and led to the expected amines. This methodology has allowed the synthesis of new aminodiazines and an improvement in the yield of various aminodiazines previously described. This reaction was used for the preparation of an aza analogue of Nevirapine.

Synthesis of Derivatives of Pyrazinopyridimidin-4-ones

Dennin, F.,Blondeau, D.,Sliwa, H.

, p. 1639 - 1643 (2007/10/02)

3-Alkoxy-2-aminopyrazines have been condensed with ethyl ethoxymethylenemalonate and isopropylidene methoxymethylenemalonate to afford 9-alkoxypyrazinopyrimidin-4-ones substituted in the first case by an ethoxycarbonyl group at 3 position.

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