4774-10-1Relevant articles and documents
Discovery of AZD-2098 and AZD-1678, Two Potent and Bioavailable CCR4 Receptor Antagonists
Kindon, Nicholas,Andrews, Glen,Baxter, Andrew,Cheshire, David,Hemsley, Paul,Johnson, Timothy,Liu, Yu-Zhen,McGinnity, Dermot,McHale, Mark,Mete, Antonio,Reuberson, James,Roberts, Bryan,Steele, John,Teobald, Barry,Unitt, John,Vaughan, Deborah,Walters, Iain,Stocks, Michael J.
, p. 981 - 986 (2017)
N-(5-Bromo-3-methoxypyrazin-2-yl)-5-chlorothiophene-2-sulfonamide 1 was identified as a hit in a CCR4 receptor antagonist high-throughput screen (HTS) of a subset of the AstraZeneca compound bank. As a hit with a lead-like profile, it was an excellent sta
Peptide deformylase inhibitors
-
Page/Page column, (2014/12/09)
The present invention relates to a compound of Formula (I): or a pharmaceutically acceptable salt thereof, corresponding pharmaceutical compositions, compound preparation and treatment methods directed to bacterial infections and inhibition of bacterial peptide deformylase (PDF) activity.
PEPTIDE DEFORMYLASE INHIBITORS
-
Page/Page column, (2014/02/15)
The present invention relates to a compound of Formula (I): or a pharmaceutically acceptable salt thereof, corresponding pharmaceutical compositions, compound preparation and treatment methods directed to bacterial infections and inhi-bition of bacterial peptide deformylase (PDF) activity