6550-96-5

Upstream product

• 70925-16-5 cis-cyclohexane-dicarboxylic acid-(1.4)-diamide 
• 14571-47-2 (1s,4s)-cyclohexane-1,4-dicarbonyl dichloride 
• 619-81-8 cyclohexane-1,4-dicarboxylic acid 
• 94-60-0 dimethyl 1,4-cyclohexane dicarboxylate 
• 619-81-8 cis-cyclohexane-1,4-dicarboxylic acid 

Downstream Products

• 619-82-9 trans-hexahydroterephthalic acid 
• 619-81-8 cis-cyclohexane-1,4-dicarboxylic acid 
• 90245-46-8 ((μ-trans-1,4-dicyanocyclohexane)pentaammineruthenium(III))aquotetraamminecobalt(III) trifluoromethanesulfonate 
• 1312812-80-8 tert-butyl {[cis-4-({[(2-phenylquinolin-4-yl)carbonyl]amino}methyl)cyclohexyl]methyl}carbamate 
• 2680-24-2 cis-1,4-bis-benzaminomethyl-cyclohexane 
• 10029-09-1 cis-cyclohexane-1,4-diyldimethanamine 
• 70924-83-3 cis-1,4-bis-acetylaminomethyl-cyclohexane 

Relevant academic research and scientific papers

METHOD FOR PRODUCING TRANS-BIS(AMINOMETHYL)CYCLOHEXANE, METHOD FOR PRODUCING BIS(ISOCYANATOMETHYL)CYCLOHEXANE, BIS(ISOCYANATOMETHYL)CYCLOHEXANE, POLYISOCYANATE COMPOSITION, AND POLYURETHANE RESIN

A method for producing trans-bis(aminomethyl)cyclohexane includes a trans-isomerization step in which cis-dicyanocyclohexane is isomerized into trans-dicyanocyclohexane by heating dicyanocyclohexane containing cis-dicyanocyclohexane in the presence of a t

METHOD FOR PRODUCING TRANS-1,4-BIS(AMINOMETHYL)CYCLOHEXANE

A method for producing trans-1,4-bis(aminomethyl)cyclohexane includes a nuclear hydrogenation step of producing a hydrogenated terephthalic acid or terephthalic acid derivative by nuclear hydrogenation of a terephthalic acid or terephthalic acid derivative, the terephthalic acid or terephthalic acid derivative being at least one selected from the group consisting of terephthalic acid, terephthalic acid ester, and terephthalic acid amide; a cyanation step of treating the hydrogenated terephthalic acid or terephthalic acid derivative with ammonia, thereby producing 1,4-dicyanocyclohexane, and producing trans-1,4-dicyanocyclohexane from the obtained 1,4-dicyanocyclohexane; and an aminomethylation step of treating the trays-1,4-dicyanocyclohexane with hydrogen, thereby producing trans-1,4-bis(aminomethyl)cyclohexane. Metal oxide is used as a catalyst in the cyanation step, and the obtained trans-1,4-dicyanocyclohexane has a metal content of 3000 ppm or less.

Design of small molecule inhibitors of acetyl-CoA carboxylase 1 and 2 showing reduction of hepatic malonyl-CoA levels in vivo in obese Zucker rats

Inhibition of acetyl-CoA carboxylases has the potential for modulating long chain fatty acid biosynthesis and mitochondrial fatty acid oxidation. Hybridization of weak inhibitors of ACC2 provided a novel, moderately potent but lipophilic series. Optimization led to compounds 33 and 37, which exhibit potent inhibition of human ACC2, 10-fold selectivity over inhibition of human ACC1, good physical and in vitro ADME properties and good bioavailability. X-ray crystallography has shown this series binding in the CT-domain of ACC2 and revealed two key hydrogen bonding interactions. Both 33 and 37 lower levels of hepatic malonyl-CoA in vivo in obese Zucker rats.