65500-83-6Relevant academic research and scientific papers
Design and synthesis of non-hydroxamate histone deacetylase inhibitors: Identification of a selective histone acetylating agent
Suzuki, Takayoshi,Matsuura, Azusa,Kouketsu, Akiyasu,Hisakawa, Shinya,Nakagawa, Hidehiko,Miyata, Naoki
, p. 4332 - 4342 (2007/10/03)
A series of suberoylanilide hydroxamic acid (SAHA)-based non-hydroxamates was designed, synthesized, and evaluated for their histone deacetylase (HDAC) inhibitory activity. Among these, methyl sulfoxide 15 inhibited HDACs in enzyme assays and caused hyperacetylation of histone H4 while not inducing the accumulation of acetylated α-tubulin in HCT116 cells.
Synthese et proprietes de monomeres acryliques porteurs d'un groupement fonctionnel acylant. Preparation d'un nouveau copolymere acylant pour l'immobilisation des biomolecules
Joyeau, Roger,Brown, Eric
, p. 391 - 394 (2007/10/02)
Carboxylic acids bearing an ω-acrylamido group were reacted with mercaptothiazoline in the presence of DCC to give the corresponding N-acyl thiazolidin-2-thiones (3 - 5) in good yields.On treatment with benzylamine, piperidine or aniline, these acyl deriv
