65511-99-1

Upstream product

• 39151-19-4 1-(3,5-dimethoxyphenyl)ethan-1-one 
• 4009-98-7 (methoxymethyl)triphenylphosphonium chloride 
• 929030-80-8 2-(3',5'-dimethoxyphenyl)-1-methoxypropene 

Downstream Products

• 1296698-87-7 (S)-di-tert-butyl 1-(2-(3,5-dimethoxyphenyl)-1-oxopropan-2-yl)hydrazine-1,2-dicarboxylate 

Relevant academic research and scientific papers

The proline-catalyzed asymmetric amination of branched aldehydes

An efficient access to configurationally stable α,β- disubstituted α-amino aldehydes, oxazolidinones, and α-amino acids has been presented. Starting from simple and easily available racemic aldehydes, the α-aminated products were obtained using azodicarboxylates as the nitrogen source in up to 86 % ee and moderate to excellent yield. These products could further be converted both into the corresponding α-amino alcohols and, depending on the residue of the azodicarboxylates and the reaction conditions, into the oxazolidinones. On the other hand, oxidation towards the carboxylic acid and cleavage of the hydrazide bond under mild conditions revealed the free α-alkylated phenylglycine derivative. Wiley-VCH Verlag GmbH & Co. KGaA, 2007.

Proline-catalysed asymmetric amination of α,α-disubstituted aldehydes: Synthesis of configurationally stable enantioenriched α-aminoaldehydes

Proline-catalysed animation of α,α-disubstituted racemic aldehydes with azodicarboxylates proceeds smoothly to give configurationally stable scalemic aldehydes and oxazolidinones in up to 86% ee.