6552-61-0Relevant articles and documents
Novel tricyclic quinazolinimines and related tetracyclic nitrogen bridgehead compounds as cholinesterase inhibitors with selectivity towards butyrylcholinesterase
Decker, Michael,Krauth, Fabian,Lehmann, Jochen
, p. 1966 - 1977 (2007/10/03)
Tetracyclic nitrogen bridgehead compounds, dibenzodiazecines and tricyclic quinazolinimines, in which the size of the alicyclic ring system and the length of the alkyl chain between the quinazolinimine moiety and a phenyl ring connected to the imine nitrogen atom were changed systematically, were synthesized and their ability to inhibit acetyl- and butyrylcholinesterase (AChE/BChE), respectively, was evaluated. Moderate and strong inhibitors of BChE-compared to galanthamine and rivastigmine-were identified, which show mixed affinities or are moderately or highly selective towards BChE, respectively.
Reactions of 1,2,3,4-Tetrahydroisoquinoline Derivatives with Sulfur
Ajzert, Ilona K.,Takacs, Kalman
, p. 1061 - 1064 (2007/10/02)
1,2,3,4-Tetrahydroisoquinolines react with sulfur in pyridine to give two different types of products, depending on the structure of the starting compounds. 1-Substituted derivatives 1 undergo partial dehydrogenation with formation of the corresponding 3,4-dihydroisoquinolines 3. 1,2,3,4-Tetrahydroisoquinolines 5 bearing no substituent in 1-position yield the 3,4-dihydro-1(2H)isoquinolinethiones 6, comprising a new and simple synthesis of compounds 6.
