655224-10-5Relevant academic research and scientific papers
Affinity-Based Tagging of Protein Families with Reversible Inhibitors: A Concept for Functional Proteomics
Hagenstein, Miriam C.,Mussgnug, Jan H.,Lotte, Kirsten,Plessow, Regina,Brockhinke, Andreas,Kruse, Olaf,Sewald, Norbert
, p. 5635 - 5638 (2003)
Kinases can be tagged with an engineered chemical probe that comprises a reversibly binding protein ligand, a photoreactive group (4-benzoylphenylalanine), and a fluorescent reporter group (carboxyfluorescein). This principle, which does not require irrev
Monovalent and bivalent fibrin-specific MRI contrast agents for detection of thrombus
Nair, Shrikumar A.,Kolodziej, Andrew F.,Bhole, Gandhali,Greenfield, Matthew T.,McMurry, Thomas J.,Caravan, Peter
supporting information; experimental part, p. 4918 - 4921 (2009/02/08)
Probing in contrast: Four gadolinium-DTPA moieties (DTPA = diethylenetriaminepentaacetic acid) and two fibrin-specific cyclic peptides are linked by a compact triethylenetetraamine core (see scheme) to create a highly sensitive probe for molecular MR imaging of thrombosis. The contrast agent has a high molecular relaxivity, and the dual peptide construct provides five-fold higher fibrin affinity than the monovalent analogue. This bivalent probe showed significant specific thrombus uptake in an in vivo model of thrombosis. (Figure Presented).
