655225-49-3

Upstream product

• 122-04-3 4-nitro-benzoyl chloride 

Downstream Products

• 655225-67-5 (3-methyl-1-{4-[(2-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-butyl)-phosphonic acid dimethyl ester 
• 655225-61-9 [3-methyl-1-(4-prop-2-ynylamino-benzoylamino)-butyl]-phosphonic acid dimethyl ester 
• 655225-55-1 [1-(4-amino-benzoylamino)-3-methyl-butyl]-phosphonic acid dimethyl ester 

Relevant academic research and scientific papers

Quinazoline antifolate thymidylate synthase inhibitors: Replacement of glutamic acid by aminophosphonic acids

The synthesis of six analogues of the potent thymidylate synthase (TS) inhibitor N-[4-[N-[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinoyl)-methyl] -N-prop-2-ynylamino]benzoyl]-L-glutamic acid 2 is described in which the glutamic acid residue has been replaced