655225-64-2Relevant academic research and scientific papers
Quinazoline antifolate thymidylate synthase inhibitors: Replacement of glutamic acid by aminophosphonic acids
Makowski, Maciej,Pawelczak, Krzysztof,Kafarski, Pawel,Dzik, Jolanta M.,Golos, Barbara,Balinska, Malgorzata,Rode, Wojciech
, p. 1639 - 1651 (2007/10/03)
The synthesis of six analogues of the potent thymidylate synthase (TS) inhibitor N-[4-[N-[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinoyl)-methyl] -N-prop-2-ynylamino]benzoyl]-L-glutamic acid 2 is described in which the glutamic acid residue has been replaced
