655228-31-2Relevant academic research and scientific papers
O-N Intramolecular acyl migration strategy in water-soluble prodrugs of taxoids
Skwarczynski, Mariusz,Sohma, Youhei,Kimura, Maiko,Hayashi, Yoshio,Kimura, Tooru,Kiso, Yoshiaki
, p. 4441 - 4444 (2007/10/03)
We synthesized a highly water-soluble canadensol prodrug 6 that formed canadensol 3 by a simple pH-dependent chemical mechanism via the O-N intramolecular acyl migration of the isobutyryl group. This prodrug, a 2′-O-isobutyryl isoform of 3, has no additio
