655237-66-4

Basic information

• Product Name: (2R,3R,4R,5S,6S)-acetic acid 4,5-diacetoxy-2-acetoxymethyl-6-(3-bromophenyl)tetrahydropyran-3-yl ester
• Synonyms: (2R,3R,4R,5S,6S)-acetic acid 4,5-diacetoxy-2-acetoxymethyl-6-(3-bromophenyl)tetrahydropyran-3-yl ester
• CAS NO: 655237-66-4
• Molecular Weight: 487.301
• Mol File: 655237-66-4.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: (2R,3R,4R,5S,6S)-acetic acid 4,5-diacetoxy-2-acetoxymethyl-6-(3-bromophenyl)tetrahydropyran-3-yl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,3R,4R,5S,6S)-acetic acid 4,5-diacetoxy-2-acetoxymethyl-6-(3-bromophenyl)tetrahydropyran-3-yl ester(655237-66-4)
• EPA Substance Registry System: (2R,3R,4R,5S,6S)-acetic acid 4,5-diacetoxy-2-acetoxymethyl-6-(3-bromophenyl)tetrahydropyran-3-yl ester(655237-66-4)

Safety Data

• Hazardous Substances Data: 655237-66-4(Hazardous Substances Data)

Upstream product

• 591-18-4 1-Bromo-3-iodobenzene 
• 572-09-8 2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide 
• 108-36-1 1,3-dibromobenzene 
• 108-24-7 acetic anhydride 
• 111762-31-3 3-bromophenyl magnesium bromide 
• 6919-96-6 2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide 

Downstream Products

• 852204-51-4 (1S)-2,3,4,6-tetra-O-acetyl-1,5-anhydro-1-(3'-{[tert-butyl(dimethyl)silyl]oxy}-4'-{(2S,3R)-3-[(3S)-3-{[tert-butyl(dimethyl)silyl]oxy}-3-(4-fluorophenyl)propyl]-4-oxo-1-phenylazetidin-2-yl}biphenyl-3-yl)-D-glucitol 

Relevant articles and documents

Nickel-catalyzed reductive coupling of glucosyl halides with aryl/vinyl halides enabling β-selective preparation of C-aryl/vinyl glucosides

This work describes stereoselective preparation of β-C-aryl/vinyl glucosides via mild Ni-catalyzed reductive arylation and vinylation of C1-glucosyl halides with aryl and vinyl halides. A broad range of aryl halides and vinyl halides were employed to yield C-aryl/vinyl glucosides in 42%–93% yields. Good to excellent β-selectivities were obtained for C-glucosides by using tridentate ligand.

Anti-hypercholesterolemic biaryl azetidinone compounds

This invention provides cholesterol absorption inhibitors of Formula I: and the pharmaceutically acceptable salts thereof, wherein R12 is an alkyl, alkeny or alkynyl group mono- or poly-substituted with —OH, —COOH or a combination of —OH and —COOH, and R9 contains an alkyl, alkeny or alkynyl group substituted with a heterocyclic ring, amino or sulfonyl. The compounds are useful for lowering plasma cholesterol levels, particularly LDL cholesterol, and for treating atherosclerosis and preventing atherosclerotic disease events.

4-BIARYLYL-1-PHENYLAZETIDIN-2-ONES

4-Biarylyl-1-phenylazetidin-2-ones useful for the treatment of hypercholesterolemia are disclosed. The compounds are of a general formula (I) in which formula (II) represents an aryl or heteroaryl residue, Ar represents an aryl residue; U is a two to six atom chain; and the R’s represent substituents.