655246-58-5Relevant academic research and scientific papers
Cell penetrable peptoid carrier vehicles: synthesis and evaluation.
Peretto, Ilaria,Sanchez-Martin, Rosario M,Wang, Xui-hong,Ellard, John,Mittoo, Stifun,Bradley, Mark
, p. 2312 - 2313 (2003)
Using a highly efficient solid-phase route a series of fluorescein conjugated peptoid oligomers were synthesised and observed to display remarkable cell penetrating properties, offering the possibility of highly efficient cellular targeting.
Amino fullerene and preparation method thereof, and method for preparing modified titanium carbide nano-sheets by using amino fullerene
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Paragraph 0043-0045, (2020/03/09)
The invention discloses amino fullerene and a preparation method thereof, and a method for preparing modified titanium carbide nano-sheets by using the amino fullerene, and relates to the technical field of functional organic molecule design and synthesis and preparation of nanometer modified additives. The preparation method comprises: carrying out an etching reaction on carbon-aluminum-titaniumunder the action of lithium fluoride and hydrochloric acid to generate titanium carbide precipitate, adding deionized water, and carrying out ultrasonic centrifugation to obtain a titanium carbide nano-sheet suspension; introducing a primary amine active group to a fullerene sphere, and then adjusting the pH value to weak acidity, so the amino fullerene generates an ammonium salt; and making the amino fullerene ammonium salt act with titanium carbide through electrostatic attraction to generate the amino fullerene modified titanium carbide nano-sheets. According to the invention, by using thefullerene ammonium salt with positive charges and titanium carbide, the fullerene ammonium salt can be effectively adsorbed on the surface of the titanium carbide under the action of electrostatic attraction so as to prevent agglomeration; and the product can be applied to the fields of photocatalytic organic reactions, lubricating oil additives, metal working fluid additives, flame-retardant material additives and the like.
Peptoidic amino- and guanidinium-carrier systems: Targeted drug delivery into the cell cytosol or the nucleus
Schr?der, Tina,Niemeier, Nicole,Afonin, Sergii,Ulrich, Anne S.,Krug, Harald F.,Br?se, Stefan
, p. 376 - 379 (2008/09/18)
Efficient drug delivery is essential for many therapeutic applications. Some cell-penetrating peptides, peptide mimetics, and peptoids express transport function that, however, lack in most cases specific intracellular destination. In this study, carrier-peptoids with either amino or guanidinium side chains, were investigated with regard to their cellular uptake, toxicity, and intracellular localization. Transport specifically to the cytosol or to the nuclei was observed, thus providing a powerful tool for targeted drug delivery.
Peptoid dendrimers-microwave-assisted solid-phase synthesis and transfection agent evaluation
Diaz-Mochon, Juan J.,Fara, Mario A.,Sanchez-Martin, Rosario M.,Bradley, Mark
, p. 923 - 926 (2008/09/17)
Three generations of peptoid-based dendrimers were synthesised by solid-phase methods, using N-Fmoc-N-(6-N′-Fmoc-aminohexyl)-glycine as both the initiator core and the monomer unit, which offer an unusual dendrimeric periphery composed of both secondary and primary amines. The third generation compound proved to be an efficient mediator of transfection while displaying minimal cytotoxicity.
