655253-61-5Relevant academic research and scientific papers
Novel thienopyrimidine and thiazolopyrimidine kinase inhibitors with activity against Tie-2 in vitro and in vivo
Luke, Richard W.A.,Ballard, Peter,Buttar, David,Campbell, Leonie,Curwen, Jon,Emery, Steve C.,Griffen, Alison M.,Hassall, Lorraine,Hayter, Barry R.,Jones, Cliff D.,McCoull, William,Mellor, Martine,Swain, Mike L.,Tucker, Julie A.
scheme or table, p. 6670 - 6674 (2010/06/12)
The SAR and improvement in potency against Tie2 of novel thienopyrimidine and thiazolopyrimidine kinase inhibitors are reported. The crystal structure of one of these compounds bound to the Tie-2 kinase domain is consistent with the SAR. These compounds h
