65527-63-1 Usage
Uses
Used in Pharmaceutical Industry:
Ergoline-8-carboxamide, 9,10-didehydro-N,N-diethyl-6-propyl-, (8b)is used as a research chemical for studying the effects of psychoactive substances on the human brain. Its structural similarity to LSD allows scientists to explore the mechanisms of action and potential therapeutic applications of hallucinogenic compounds.
Used in Ethnobotanical Research:
In ethnobotanical studies, LSA is used to understand the traditional uses of plants containing this alkaloid, such as the Hawaiian baby woodrose, which has been used for its psychoactive properties in various cultural practices.
Used in Forensic Toxicology:
Ergoline-8-carboxamide, 9,10-didehydro-N,N-diethyl-6-propyl-, (8b)is utilized in forensic toxicology for the identification and analysis of controlled substances in cases involving drug abuse or intoxication.
Check Digit Verification of cas no
The CAS Registry Mumber 65527-63-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,5,5,2 and 7 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 65527-63:
(7*6)+(6*5)+(5*5)+(4*2)+(3*7)+(2*6)+(1*3)=141
141 % 10 = 1
So 65527-63-1 is a valid CAS Registry Number.
65527-63-1Relevant academic research and scientific papers
Synthesis and LSD-like discriminative stimulus properties in a series of N(6)-alkyl norlysergic acid N,N-diethylamide derivatives
Hoffman,Nichols
, p. 1252 - 1255 (2007/10/02)
A convenient method for the synthesis of N(6)-alkyl norlysergic acid N,N-diethylamide derivatives was developed. A series of these compounds was synthesized and tested for substitution in the two-lever drug discrimination assay, in rats trained to discriminate injections of d-LSD tartrate (185.5 nmol/kg, ip) from saline. A dose-response curve for each of the compounds in the series was generated. Structure-activity relationships were developed, based on comparison of the estimated ED50 values from these curves. Of the compounds that substituted for LSD, the N(6)-ethyl and -allyl were approximately 2-3 times more potent than LSD itself. The N(6)-propyl was equipotent to LSD, while the isopropyl derivative was half as active. The n-butyl compound was 1 order of magnitude less potent than LSD, suggesting a similarity to the SAR of certain serotonin and dopamine agonists. By contrast, no generalization occurred to norlysergic acid N,N-diethylamide and the N(6)-2-phenethyl derivative.
