65527-79-9Relevant academic research and scientific papers
Asymmetric hydroformylation of allylic alcohols catalyzed by Rh(I)-(R,S)-BINAPHOS
Nozaki, Kyoko,Li, Wen-Ge,Horiuchi, Toshihide,Takaya, Hidemasa
, p. 4611 - 4614 (2007/10/03)
Chiral lactones 4a-e were synthesized by the asymmetric hydroformylation of allylic alcohols 1a-e and 5 catalyzed by a rhodium(I) complex of a chiral phosphine-phosphite, (R,S)-BINAPHOS, followed by the silver(I) oxidation.
Regioselective Hydrogenation of Unsymmetrically Substituted Cyclic Anhydrides Catalyzed by Ruthenium Complexes with Phosphine Ligands
Ikariya, Takao,Osakada, Kohtaro,Ishii, Youichi,Osawa, Shoichi,Saburi, Masahiko,Yoshikawa, Sadao
, p. 897 - 898 (2007/10/02)
Regioselective hydrogenation of unsymmetrically substituted cyclic anhydrides catalyzed by ruthenium complexes with mono-, di-, or triphosphine ligands produced the corresponding two isomeric lactones, where the regioselectivity was influenced by the bulkiness of substituent(s) on the anhydrides and of the phosphine ligands of catalyst.
Asymmetric Synthesis of 2-Substituted Butyrolactones and Valerolactones
Meyers, A. I.,Yamamoto, Yukio,Mihelich, Edward D.,Bell, Richard A.
, p. 2792 - 2796 (2007/10/02)
The use of chiral oxazolines 1, 2, 5, and 8 under asymmetrically induced alkylation conditions gave α-substituted oxazolines 3, 6, 9, and 13 which were hydrolyzed to α-substituted butyro- and valerolactones 4 and 11.Either enantiomer of the lactones could be prepared in predictable absolute configuration by reversing the order of alkyl group introduction.The lactones were prepared in 60-86 percent enantiomeric excess which was determined by either chemical correlation or high-pressure liquid chromatography of the diastereomers 10.
