6554-00-3

Basic information

• Product Name: Guanine ribonucleotidyl-(3-5)-adenosine
• Synonyms: Guanosine,adenylyl-(5'-3');EINECS 229-480-1;Adenylyl-(5'.3')-guanosine;Guanine ribonucleotidyl-(3'-5')-adenosine
• CAS NO: 6554-00-3
• Molecular Formula: C₂₀H₂₅N₁₀O₁₁P
• Molecular Weight: 612.453
• Mol File: 6554-00-3.mol

Chemical Properties

• CAS DataBase Reference: Guanine ribonucleotidyl-(3-5)-adenosine(CAS DataBase Reference)
• NIST Chemistry Reference: Guanine ribonucleotidyl-(3-5)-adenosine(6554-00-3)
• EPA Substance Registry System: Guanine ribonucleotidyl-(3-5)-adenosine(6554-00-3)

Safety Data

• Hazardous Substances Data: 6554-00-3(Hazardous Substances Data)

Upstream product

• 1177254-66-8 5'-CGACGA-3' 
• 29886-19-9 2',3'-di-O-acetyladenosine 
• 76951-75-2 C₈₃H₇₁ClN₁₁O₁₈P 
• 634-02-6 guanosine 2',3'-cyclic monophosphate 
• 58-61-7 adenosine 

Downstream Products

• 634-02-6 guanosine 2',3'-cyclic monophosphate 
• 58-61-7 adenosine 
• 117-68-0 guanosine 3'-monophosphate 
• 130-50-7 guanosine 2'-monophosphate 

Relevant articles and documents

Base moiety selectivity in cleavage of short oligoribonucleotides by di- and tri-nuclear Zn(II) complexes of azacrown-derived ligands

Cleavage of 6-mer oligoribonucleotides by the dinuclear Zn2+ complex of 1,3-bis[(1,5,9-triazacyclododecan-3-yl)oxymethyl]benzene (L 1) and the trinuclear Zn2+ complex of 1,3,5-tris[(1,5,9- triazacyclododecan-3-yl)oxymethyl

Efficient and selective cleavage of RNA oligonucleotides by calix[4]arene-based synthetic metallonucleases

Di- and trinuclear copper(II) complexes of [12]aneN3 macrocycles anchored at the upper rim of cone calix[4]arenes in 1,2-, 1,3-, and 1,2,3-positions were investigated as cleaving agents of 6-, 7-, and 17-meric oligoribonucleotides. A kinetic investigation of the cleavage reactions was carried out using gel electrophoresis to separate and analyze reactants and products having a radioactive phosphate label in the terminal opposition. The degree of cooperation was assessed on the basis of a comparison with rates of cleavage by mononuclear controls. A remarkable selectivity of cleavage of the CpA phosphodiester bond was observed for all metal complexes, in sharp contrast with the UpU and UpG selectivity previously observed in the cleavage of diribonucleoside monophosphates by the same metal complexes. The highest rate acceleration, brought about in the cleavage of the 5′-pCpA bond in hexanucleotide 9 by 50 μM trinuclear complex 5-Cu3 (water solution, pH 7.4, 50°C), amounts to 5 × 105-fold, as based on the estimated background reactivity of the CpA dimer. Selectivity in the cleavage of oligoribonucleotides by copper(II) complexes closely resembles that experienced by ribonuclease A and by a number of metal-independent RNase A mimicks. The possible role of the dianionic phosphate at the 5′-terminal positions as a primary anchoring site for the metal catalyst is discussed.

CESIUM FLUORIDE PROMOTES SYNTHESYS OF RIBOOLIGONUCLEOTIDES VIA PHOSPHOTRIESTER APPROACH

In the presence of cesium fluoride, the reactions of a fully protected 5'-O-dimethoxytrityl-2'-O-tetrahydropyranyl-N-acylnucleoside 3'-(4-chlorophenyl, 5-chloro-8-quinolyl) phosphates with 5'-hydroxyl nucleosides proceeded rapidly under mild conditions to afford the corresponding ribonucleoside monophosphates in good yields.