65548-55-2

Usage

Uses

Used in Pharmaceutical Industry:
3',4',7,8-Tetramethoxyflavone is used as a potential therapeutic agent for various health conditions due to its antioxidant properties and potential health benefits. Its exact applications and efficacy are yet to be studied in detail.
Used in Nutraceutical Industry:
3',4',7,8-Tetramethoxyflavone is used as a nutraceutical ingredient in dietary supplements and functional foods for its potential health benefits, including antioxidant properties and support for overall well-being.
Used in Cosmetic Industry:
3',4',7,8-Tetramethoxyflavone may be used in cosmetic products for its potential antioxidant and skin health benefits, although its specific applications and efficacy in this industry are yet to be fully explored.

Upstream product

• 154045-69-9 1,2-dimethoxy-3-(methoxymethoxy)benzene 
• 460744-76-7 1-(3,4-dimethoxyphenyl)-3-(2-hydroxy-3,4-dimethoxyphenyl)-1,3-propanedione 
• 460744-74-5 6-acetyl-2,3-dimethoxyphenyl-3,4-dimethoxybenzoate 
• 3535-37-3 3,4-dimethoxybenzoic acid chloride 
• 5396-18-9 2'-hydroxy-3',4'-dimethoxyacetophenone 
• 1026512-39-9 (E)-3-(3,4-Dimethoxy-phenyl)-acrylic acid 2,3-dimethoxy-phenyl ester 
• 5150-42-5 2,3-dimethoxyphenol 
• 2316-26-9 3,4-dimethoxycinnamic acid 
• 64-17-5 ethanol 
• 112863-98-6 (2RS:3SR)-2,3-dibromo-3-(3,4-dimethoxy-phenyl)-1-(3,4-dimethoxy-2-acetoxy-phenyl)-propanone-⁽¹⁾ 
• 94285-19-5 2'-hydroxy-3',4',3,4-tetramethoxychalcone 

Downstream Products

• 3440-24-2 3',4',7,8-tetrahydroxyflavone 

Relevant academic research and scientific papers

Convenient synthesis and physiological activities of flavonoids in Coreopsis lanceolata L. petals and their related compounds

Chalcones, flavanones, and flavonols, including 8-methoxybutin isolated from Coreopsis lanceolata L. petals, were successfully synthesized with total yields of 2–59% from O-methylpyrogallols using the Horner–Wadsworth–Emmons reaction as a key reaction. Au

Novel synthesised flavone derivatives provide significant insight into the structural features required for enhanced anti-proliferative activity

With many cancers showing resistance to current chemotherapies, the search for novel anti-cancer agents is attracting considerable attention. Natural flavonoids have been identified as useful leads in such programmes. However, since an in-depth understanding of the structural requirements for optimum activity is generally lacking, further research is required before the full potential of flavonoids as anti-proliferative agents can be realised. Herein a broad library of 76 methoxy and hydroxy flavones, and their 4-thio analogues, was constructed and their structure-activity relationships for anti-proliferative activity against the breast cancer cell lines MCF-7 (ER +ve), MCF-7/DX (ER +ve, anthracycline resistant) and MDA-MB-231 (ER -ve) were probed. Within this library, 42 compounds were novel, and all compounds were afforded in good yields and >95% purity. The most promising lead compounds, specifically the novel hydroxy 4-thioflavones 15f and 16f, were further evaluated for their anti-proliferative activities against a broader range of cancer cell lines by the National Cancer Institute (NCI), USA and displayed significant growth inhibition profiles (e.g. compound-15f: MCF-7 (GI50 = 0.18 μM), T-47D (GI50 = 0.03 μM) and MDA-MB-468 (GI50 = 0.47 μM) and compound-16f: MCF-7 (GI50 = 1.46 μM), T-47D (GI50 = 1.27 μM) and MDA-MB-231 (GI50 = 1.81 μM)). Overall, 15f and 16f exhibited 7-46 fold greater anti-proliferative potency than the natural flavone chrysin (2d). A systematic structure-activity relationship study against the breast cancer cell lines highlighted that free hydroxyl groups and the B-ring phenyl groups were essential for enhanced anti-proliferative activities. Substitution of the 4-CO functionality with a 4-CS functionality, and incorporation of electron withdrawing groups at C-4′ of the B-ring phenyl, also enhanced activity. Molecular docking and mechanistic studies suggest that the anti-proliferative effects of flavones 15f and 16f are mediated via ER-independent cleavage of PARP and downregulation of GSK-3β for MCF-7 and MCF-7/DX cell lines. For the MDA-MB-231 cell line, restoration of the wild-type p53 DNA binding activity of mutant p53 tumour suppressor gene was indicated.

Substituted benzopyranones as telomerase inhibitors

The present invention relates to benzopyranone derivatives, to methods for treating telomerase-modulated diseases, in particular cancers, with said derivatives, to a process for their preparation, to their use as medicaments and to pharmaceutical compositions comprising them.

An efficient conversion of 2'-hydroxychalcones into flavanones: Use of tetra-n-butylammonium iodide

2'-Hydroxychalcones 1 possessing different substitution patterns in rings A and B, have been found to undergo efficient isomerization to the corresponding flavanones 2 when heated in ethanol with hydrochloric acid and tetra-n-butylammonium iodide.

Synthesis and Pharmacological Evaluation of 2'-Hydroxychalcones and Flavones as Inhibitors of Inflammatory Mediators Generation

2'-Hydroxy-3,4-dimethoxy-3',4'-dimethylchalcone (3a), 2'-hydroxy-3',4',3,4-tetramethoxychalcone (3b), and their corresponding flavones, 3',4'-dimethoxy-7,8-dimethylflavone (4a) and 3',4',7,8-tetramethoxyflavone (4b), were prepared from 3,4-dimethoxycinnam